CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17832
Family Name Ras guanyl-releasing protein 3 and Protein kinase C alpha type inhibitor [(4E)-2-(hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethylidene)oxolan-2-yl]methyl 4-methoxybenzoate family
No. of Seeds 2 No. of Other Members 6
Family Centroid CFAMM00338820 Functional Category Bioactive with Natural Product
Superfamily Cysteinyl leukotriene receptor 1 and Beta-lactamase Binder Superfamily
Class Class 2015

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Leukotriene B4 receptor 1 Ligand SB-201993 Family 5 13
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 20 28
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 391
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
Glycylpeptide N-tetradecanoyltransferase 2 and Glycylpeptide N... 8 10
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Prostaglandin D2 receptor and Prostaglandin E2 receptor EP2 su... 2 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 3 17
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 3
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 7 1
Cysteinyl leukotriene receptor 1 ligand 4-oxo-7-[[3-(quinolin-... 4 17
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 18 39
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 8 9
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 1 2
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 2 0
Histamine H1 receptor and Histamine H2 receptor ligand SureCN6... 1 3
Histamine H1 receptor and Histamine H2 receptor ligand SureCN5... 3 6
Mitogen-activated protein kinase 14 inhibitor Aminopyridine N-... 3 1
DNA polymerase beta and Microtubule-associated protein tau inh... 1 1
Aldose reductase inhibitor [1-(3,5-difluoro-4-hydroxyphenyl)py... 3 2
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27619 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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