CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1785
Family Name Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptamine receptor 2B ligand AGN-PC-076LHE family
No. of Seeds 20 No. of Other Members 9
Family Centroid CFAMM00214811 Functional Category Bioactive
Superfamily Sigma non-opioid intracellular receptor 1 and D(2) dopamine receptor Binder Superfamily
Class Class 2912

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Histamine H3 receptor Ligand ABT-239 Family 8 20
Alpha-2C adrenergic receptor Ligand MK-912 Family 1 3
Histamine H3 receptor Ligand A-317920 Family 9 240
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Cytochrome P450 2D6 Inhibitor (5-phenylfuran-2-yl)methanamine ... 1 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 4 18
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 5 11
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 4
Fatty-acid amide hydrolase 1 Inhibitor Furan-2-ylmethylcarbami... 1 105
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 62
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 8 36
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
Sodium-dependent dopamine transporter and Sigma non-opioid int... 7 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 2 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 10
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Lethal(3)malignant brain tumor-like protein 1 and Lysine-speci... 1 6
Histamine H3 receptor ligand SureCN2786002 family 8 3
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Prostaglandin E2 receptor EP4 subtype ligand SureCN5653729 family 3 2
Histamine H3 receptor ligand SureCN2784769 family 12 2
Histamine H3 receptor ligand SureCN2785131 family 7 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 2 4
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
Lysosomal Pro-X carboxypeptidase inhibitor 1'-(1-benzofuran-2-... 1 0
Translocator protein inhibitor N-[(2,5-dimethoxyphenyl)methyl]... 1 0
Histamine H3 receptor ligand SureCN5218144 family 4 6
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
5-hydroxytryptamine receptor 1A ligand SureCN10513645 family 9 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 1 1
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 1
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 5 4
Protein kinase C theta type and Protein kinase C epsilon type ... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Histone deacetylase 6 and Histone deacetylase 1 inhibitor (E)-... 4 0
Putative NP ZINC02134473 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00327373 CHEMBL2069862 Bioactive 1-(1-benzofuran-2-ylmethyl)-4-[(4-ethoxyphenyl)methyl]-1,4-diazepane
CFAMM00327372 CHEMBL2069863 Bioactive 1-(1-benzofuran-2-ylmethyl)-4-[[4-(2-fluoroethoxy)phenyl]methyl]-1,4-diazepane
CFAMM00327370 CHEMBL1917286 Bioactive 1-(1-benzofuran-2-ylmethyl)-4-[[4-(2-fluoroethoxy)phenyl]methyl]piperazine
CFAMM00327376 CHEMBL2069864 Bioactive 1-(1-benzofuran-2-ylmethyl)-4-[(4-propoxyphenyl)methyl]-1,4-diazepane
CFAMM00327375 CHEMBL2069865 Bioactive 1-(1-benzofuran-2-ylmethyl)-4-[[4-(3-fluoropropoxy)phenyl]methyl]-1,4-diazepane
CFAMM00327381 CHEMBL2069964 Bioactive 1-(1-benzofuran-2-ylmethyl)-3-[[4-(2-fluoroethoxy)phenyl]methyl]imidazolidine
CFAMM00327374 CHEMBL2069861 Bioactive 1-(1-benzofuran-2-ylmethyl)-4-[(4-methoxyphenyl)methyl]-1,4-diazepane

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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