CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17859
Family Name D(2) dopamine receptor ligand 4-bromo-6-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazole family
No. of Seeds 1 No. of Other Members 2
Family Centroid CFAMM00444737 Functional Category Bioactive
Superfamily Methionine--tRNA ligase and Cannabinoid receptor 2 Binder Superfamily
Class Class 202

Cousin Family NamesSeedsMembers
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Tryptase Inhibitor Babim Family 12 90
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Neuropeptide Y receptor type 5 ligand 8-[6-(4-fluorophenyl)-1H... 2 1
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3... 4 3
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Transient receptor potential cation channel subfamily V member... 4 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... 6 12
Transient receptor potential cation channel subfamily V member... 6 2
Methionine--tRNA ligase inhibitor N-[(4R)-6,8-dibromo-1,2,3,4-... 1 1
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 2 4
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00444737 CHEMBL488977 Bioactive 4-bromo-6-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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