CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17875
Family Name Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-050GR6 family
No. of Seeds 5 No. of Other Members 0
Family Centroid CFAMM00444857 Functional Category Bioactive
Superfamily Macrophage colony-stimulating factor 1 receptor and Serine/threonine-protein kinase mTOR Binder Superfamily
Class Class 1031

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 4 8
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Tyrosine-protein kinase receptor TYRO3 and Mitogen-activated p... 3 7
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Epidermal growth factor receptor ligand N-[3-[2-(4-morpholin-4... 2 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 2 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cathepsin S and Cathepsin K inhibitor 2-cyano-N-[(2R)-1-phenyl... 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Transient receptor potential cation channel subfamily V member... 3 2
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00444858 CHEMBL489881 Bioactive AGN-PC-050GR3
CFAMM00444857 CHEMBL489883 Bioactive AGN-PC-050GR6
CFAMM00444856 CHEMBL489684 Bioactive AGN-PC-050GR2
CFAMM00444855 CHEMBL521580 Bioactive AGN-PC-050GR5

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26413 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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