CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17897
Family Name P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]-2-(4-cyanophenyl)acetamide family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00444978 Functional Category Bioactive
Superfamily P2X purinoceptor 7 and Protein farnesyltransferase subunit beta Binder Superfamily
Class Class 144

Cousin Family NamesSeedsMembers
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Prothrombin Inhibitor Ximelegatran Family 8 157
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Neuromedin-K receptor Ligand SB222200 Family 17 235
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
RAC-gamma serine/threonine-protein kinase Inhibitor GDC-0068 F... 20 29
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
ABC294640 family 5 75
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 3
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Beta-secretase 1 inhibitor 3-[2-amino-6-(2-methylphenyl)quinol... 5 2
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 2 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Prothrombin inhibitor N-[(6-amino-2-methylpyridin-3-yl)methyl]... 2 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Transient receptor potential cation channel subfamily V member... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
P2X purinoceptor 7 inhibitor N'-quinolin-5-yladamantane-1-carb... 2 9
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 1 1
Transient receptor potential cation channel subfamily V member... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00444978 CHEMBL491933 Bioactive N-[1-[(Z)-[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]-2-(4-cyanophenyl)acetamide
CFAMM00444977 CHEMBL491916 Bioactive 2-(4-chlorophenyl)-N-[1-[(Z)-[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]acetamide
CFAMM00444974 CHEMBL490741 Bioactive N-[1-[(Z)-[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]-2-(4-methylsulfanylphenyl)acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26233 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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