CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17911
Family Name Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibitor ZINC00027781 family
No. of Seeds 1 No. of Other Members 5
Family Centroid CFAMM00158885 Functional Category Bioactive
Superfamily Cruzipain and Aurora kinase B Binder Superfamily
Class Class 4886

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Alpha-2A adrenergic receptor Ligand Brimonidine Family 3 6
Histamine H1 receptor Ligand Triprolidine Family 19 316
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Histamine H1 receptor Ligand Mizolastine Family 14 603
SUR2-type K(ATP) channel Ligand Pinacidil Family 1 8
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Transient receptor potential cation channel subfamily V member... 6 66
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
C-Jun N-terminal kinase Inhibitor CC-930 Family 2 9
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Transient receptor potential cation channel subfamily V member... 2 26
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Farnesyl pyrophosphate synthase Inhibitor [2-(benzoimidazol-1-... 2 16
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
D(2) dopamine receptor Ligand PD-135146 Family 5 11
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Reverse transcriptase Inhibitor PT-109 Family 6 7
Metabotropic glutamate receptor 5 Ligand 2-(3-bromophenyl)-7-m... 3 1
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 1 4
Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... 7 6
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Transient receptor potential cation channel subfamily V member... 4 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
Motilin receptor ligand SureCN2004322 family 2 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-[3-(4-piperidi... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 3 6
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Microtubule-associated protein tau and Thyrotropin receptor li... 1 2
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 0
Coagulation factor X and Prothrombin inhibitor SureCN6578740 f... 1 0
Nonstructural protein 1 and Cruzipain inhibitor CHEMBL1331578 ... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543