CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17932
Family Name Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methylpiperazin-1-yl)methyl]phenyl]phenyl]methyl]-1,3-benzodioxole-5-carboxamide family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00445130 Functional Category Bioactive with Natural Product
Superfamily Myeloperoxidase Inhibitor AZD5904 Superfamily
Class Class 893

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Myeloperoxidase Inhibitor AZD5904 Family 1 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Histamine H1 receptor Ligand MDL-105212 Family 16 56
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
DNA topoisomerase 1 Inhibitor NSC-341622 Family 1 1
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 2
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 2 6
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Histamine H3 receptor ligand 1-(3,4-dimethoxyphenyl)-4-(4-pent... 2 0
D(2) dopamine receptor and D(3) dopamine receptor ligand 5-bro... 3 11
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Pol polyprotein inhibitor CHEMBL305466 family 4 7
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-benzylsul... 2 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Mu-type opioid receptor ligand AGN-PC-075GCP family 2 8
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
Plasmepsin-1 and Plasmepsin-2 inhibitor N-[(2S,3S)-5-[[(2S)-1-... 1 2
Collagenase 3 and 72 kDa type IV collagenase inhibitor N-[(3,4... 1 6
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X1U ... 2 3
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 4 22
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Caspase-1 and Caspase-8 inhibitor N-[(6S)-1-[2-[[(3S)-2-hydrox... 3 1
Prothrombin inhibitor CHEMBL2448373 family 3 0
Melanocortin receptor 4 ligand [(3R,4S)-4-(4-chlorophenyl)-1-p... 5 8
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Cholinesterase and Acetylcholinesterase inhibitor 3,4,5-trimet... 1 0
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 2 20
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 4
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
C-C chemokine receptor type 3 ligand N-[(3R)-1-[(6-fluoronapht... 1 4
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
D(3) dopamine receptor ligand S33084 family 1 1
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 2 1
Protease inhibitor (2S)-N-[4-(1,3-benzodioxol-5-ylmethylamino)... 1 2
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 1 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-ben... 1 0
Prostaglandin D2 receptor ligand (E)-7-[(1S,3S,4R,5R)-4-(1,3-b... 1 0
Stilbenes Metabolite (Z)-Narceine imide Family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00445130 CHEMBL493328 Bioactive N-[[3-[3-[(3-methylpiperazin-1-yl)methyl]phenyl]phenyl]methyl]-1,3-benzodioxole-5-carboxamide
CFAMM00445129 CHEMBL551739 Bioactive 2-[1-(1,3-benzodioxole-5-carbonyl)piperidin-4-ylidene]-N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]acetamide
CFAMM00445128 CHEMBL521986 Bioactive N-[[4-fluoro-3-[3-(piperazin-1-ylmethyl)phenyl]phenyl]methyl]-1,3-benzodioxole-5-carboxamide
CFAMM00445127 CHEMBL560995 Bioactive 2-[1-(3,4-dimethoxybenzoyl)piperidin-4-ylidene]-N-[(3R)-1-[(6-fluoronaphthalen-2-yl)methyl]pyrrolidin-3-yl]acetamide
CFAMM00445131 CHEMBL493329 Bioactive N-[[3-[3-[[(3S)-3-methylpiperazin-1-yl]methyl]phenyl]phenyl]methyl]-1,3-benzodioxole-5-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24536 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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