CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17953
Family Name Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-chloro-4-(2,4-dimethylimidazol-1-yl)phenyl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-1,2,4-triazole family
No. of Seeds 9 No. of Other Members 0
Family Centroid CFAMM00445198 Functional Category Bioactive
Superfamily Glutamate receptor AMPA subtype Ligand GYKI-47261 Superfamily
Class Class 37

Cousin Family NamesSeedsMembers
Benzodiazepine receptor Ligand Midazolam Family 5 160
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-met... 7 12
Corticotropin-releasing factor receptor 1 ligand SureCN5395386... 6 5
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Platelet-activating factor receptor ligand SureCN9383514 family 4 1
Histamine H3 receptor ligand SureCN4025673 family 4 2
Cannabinoid receptor 1 ligand SureCN923882 family 12 8
Adenosine receptor A2b and Adenosine receptor A2a ligand CP-66... 3 33
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 6 18
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 5-[4-... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 2 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 4-met... 11 12
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 8-... 6 2
Vasopressin V1a receptor ligand 2-[4-[4-[(3-chlorophenyl)methy... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Metabotropic glutamate receptor 2 ligand 3-(cyclopropylmethyl)... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 5 1
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
D(3) dopamine receptor and Muscarinic acetylcholine receptor M... 8 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-(2-... 4 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1-met... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3,5-b... 4 6
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-01Z2AT... 1 10
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 17 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00445196 CHEMBL522572 Bioactive AGN-PC-077K1A
CFAMM00445195 CHEMBL524623 Bioactive 3-[2-chloro-4-(2-methylsulfanylimidazol-1-yl)phenyl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-1,2,4-triazole
CFAMM00445194 CHEMBL496714 Bioactive AGN-PC-077K1B
CFAMM00445193 CHEMBL524040 Bioactive AGN-PC-077JZ0
CFAMM00445199 CHEMBL523414 Bioactive AGN-PC-077K0L
CFAMM00445198 CHEMBL498153 Bioactive 3-[2-chloro-4-(2,4-dimethylimidazol-1-yl)phenyl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-1,2,4-triazole
CFAMM00445197 CHEMBL525360 Bioactive 3-[2-chloro-4-(2-methylimidazol-1-yl)phenyl]-5-[1-(4-chlorophenyl)cyclobutyl]-4-methyl-1,2,4-triazole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

25240 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543