CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1797
Family Name Prothrombin inhibitor (2S)-N-[[2-(aminomethyl)-5-chlorophenyl]methyl]-1-[(2R)-2-(benzylsulfonylamino)-3-methylbutanoyl]pyrrolidine-2-carboxamide family
No. of Seeds 5 No. of Other Members 11
Family Centroid CFAMM00327490 Functional Category Bioactive
Superfamily Prothrombin and Trypsin-1 Binder Superfamily 3
Class Class 1321

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 11
Substance-P receptor ligand (2S)-N-[(2S)-1-[benzyl(methyl)amin... 1 1
Prothrombin and Coagulation factor X inhibitor (2S)-N-[(4-amin... 2 3
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 16 11
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 6
Coagulation factor X inhibitor 6-chloro-N-[(3S)-1-[4-[1-(ethyl... 27 1
Prostaglandin D2 receptor 2 ligand SureCN4942606 family 2 8
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 5 37
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Prothrombin inhibitor SureCN6921523 family 4 1
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 7 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Coagulation factor X inhibitor (2S)-N-(3-aminopropyl)-2-[(3S)-... 22 15
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Coagulation factor X inhibitor 2-[(6-chloronaphthalen-2-yl)sul... 10 2
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
P2X purinoceptor 7 inhibitor (3S)-N-[[2-chloro-3-(trifluoromet... 1 6
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(4-carbamim... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00327499 CHEMBL1215086 Bioactive (2S)-N-[[2-(aminomethyl)-5-chlorophenyl]methyl]-1-[(2R)-2-(benzylsulfonylamino)-3-cyclohexylpropanoyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00327491 CHEMBL2152429 Bioactive (2S)-N-[[2-(aminomethyl)-5-chlorophenyl]methyl]-1-[(2R)-2-(benzylsulfonylamino)-4-methylpentanoyl]pyrrolidine-2-carboxamide
CFAMM00327490 CHEMBL2152428 Bioactive (2S)-N-[[2-(aminomethyl)-5-chlorophenyl]methyl]-1-[(2R)-2-(benzylsulfonylamino)-3-methylbutanoyl]pyrrolidine-2-carboxamide
CFAMM00327488 CHEMBL1229262 Bioactive (2S)-N-[[2-(aminomethyl)-5-chlorophenyl]methyl]-1-[(2R)-2-(benzylsulfonylamino)-3-cyclohexylpropanoyl]pyrrolidine-2-carboxamide
CFAMM00327501 CHEMBL1215084 Bioactive (2S)-N-[[2-(aminomethyl)-5-chlorophenyl]methyl]-1-[(2R)-2-(benzylsulfonylamino)-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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