CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM17998
Family Name Serine/threonine-protein kinase B-raf and Mitogen-activated protein kinase 3 inhibitor (NE)-N-[5-(1-methyl-3-pyridin-4-ylpyrazol-4-yl)-2,3-dihydroinden-1-ylidene]hydroxylamine family
No. of Seeds 16 No. of Other Members 5
Family Centroid CFAMM00226859 Functional Category Bioactive
Superfamily TGF-beta receptor type-1 and Hepatocyte growth factor receptor Binder Superfamily
Class Class 1666

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Vascular endothelial growth factor receptor 2 Ligand Ptk787/zk... 5 38
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
PF-4217903 family 14 65
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Metabotropic glutamate receptor 5 Ligand 3-(1-pyridin-2-yl-1h-... 3 6
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 6
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YT9... 28 20
Corticotropin-releasing factor receptor 1 ligand 3,7-dimethyl-... 3 4
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUB... 2 0
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14574... 1 2
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Tyrosine-protein kinase ITK/TSK inhibitor (3Z)-3-(6-methylindo... 2 40
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 10 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 3 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Casein kinase I isoform delta and Casein kinase I isoform epsi... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
D(3) dopamine receptor and Muscarinic acetylcholine receptor M... 8 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[7-(2-morphol... 2 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Glucocorticoid receptor ligand 6-benzyl-1-(4-fluorophenyl)-4a-... 2 0
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Methionine aminopeptidase 2 inhibitor SureCN5020175 family 1 1
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 10 2
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Nociceptin receptor ligand SureCN3543370 family 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Transient receptor potential cation channel subfamily V member... 1 0
TGF-beta receptor type-1 ligand N-(3-cyanophenyl)-2-[3-(6-meth... 4 5
Heat shock protein HSP 90-beta inhibitor 1-[1-(naphthalen-2-yl... 3 2
TGF-beta receptor type-1 ligand 6-bromo-4-(2-(6-methylpyridin-... 1 3
TGF-beta receptor type-1 ligand SureCN373106 family 4 1
Farnesyl pyrophosphate synthase inhibitor AGN-PC-080IBX family 2 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00445356 CHEMBL526479 Bioactive (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime
CFAMM00445355 CHEMBL498674 Bioactive (NE)-N-[5-[1-(1-methylpiperidin-4-yl)-3-pyridin-4-ylpyrazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24631 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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