CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18004
Family Name Cannabinoid receptor 1 ligand AGN-PC-077JWI family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00445391 Functional Category Bioactive
Superfamily Transient receptor potential cation channel subfamily V member 1 Ligand Bctc Superfamily
Class Class 846

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 16 295
Farnesyltransferase beta subunit, putative Inhibitor Lonafarni... 36 87
Transient receptor potential cation channel subfamily V member... 6 66
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Amg 423 family 7 47
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
GDC-0349 family 44 77
XL-888 family 16 85
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Reverse transcriptase Inhibitor PT-109 Family 6 7
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Cannabinoid receptor 1 Ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 18 41
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
ALK tyrosine kinase receptor ligand SureCN1600195 family 1 1
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 4 inhibitor Su... 5 13
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 9 31
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 14
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 2 0
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 1 4
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Corticotropin-releasing factor receptor 1 ligand 5-(2,4-dichlo... 5 17
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(2-amino-6... 13 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 10 0
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Transient receptor potential cation channel subfamily V member... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Corticotropin-releasing factor receptor 1 ligand 4-[(1R)-1-cyc... 5 6
Corticotropin-releasing factor receptor 1 ligand 4-(1-cyclopro... 3 0
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
B1 bradykinin receptor ligand N-[4-chloro-2-[[(1R)-1-[4-[3-flu... 5 5
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
B1 bradykinin receptor ligand N-[2-[[4-(2-chlorophenyl)-4-cyan... 2 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Coagulation factor X inhibitor SureCN1652469 family 2 1
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[(2... 3 1
Fibroblast growth factor receptor 1 and Proto-oncogene tyrosin... 2 0
P2X purinoceptor 7 inhibitor N-[(3-chloro-2-methylphenyl)methy... 7 0
Inosine-5'-monophosphate dehydrogenase inhibitor N-(4-chloroph... 1 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 1
Calpain-1 catalytic subunit inhibitor 2,6-dichloro-N-[(2S)-3,4... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00445390 CHEMBL496507 Bioactive AGN-PC-077JWH
CFAMM00445389 CHEMBL498783 Bioactive AGN-PC-077JX5
CFAMM00445388 CHEMBL497556 Bioactive AGN-PC-077JX6
CFAMM00445394 CHEMBL522395 Bioactive AGN-PC-077JWG
CFAMM00445387 CHEMBL497557 Bioactive AGN-PC-04SQI8
CFAMM00445392 CHEMBL496919 Bioactive AGN-PC-077JVS
CFAMM00445391 CHEMBL496508 Bioactive AGN-PC-077JWI

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26236 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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