CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18021
Family Name D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-PC-00EHA7 family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00188987 Functional Category Bioactive
Superfamily Histamine H3 receptor and D(2) dopamine receptor Binder Superfamily 3
Class Class 1555

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Prothrombin Inhibitor Ximelegatran Family 8 157
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Setipiprant family 5 118
CP-18770 family 6 27
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Amine oxidase [flavin-containing] B Inhibitor Lazebemide Family 2 13
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4R,... 3 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
Vasopressin V1b receptor ligand 2-[3-(3-chlorophenyl)-1-oxo-7-... 2 12
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Coagulation factor X and Prothrombin inhibitor SureCN763988 fa... 31 86
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 3A ligand SureCN8035577 family 5 4
Dipeptidyl peptidase 4 inhibitor (2S)-1-[2-[5-(aminomethyl)-2-... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Translocator protein inhibitor AGN-PC-08WI0V family 1 0
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
ALK tyrosine kinase receptor and Insulin receptor ligand 9-eth... 9 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
Cannabinoid receptor 1 ligand 5-cyano-1-[(3,5-dichlorophenyl)m... 2 0
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 4 2
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Translocator protein inhibitor N-(4-chlorophenyl)-N-methyl-2-(... 2 0
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Translocator protein inhibitor N,N-diethyl-11-(2-fluoroethyl)-... 14 9
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 14 1
D(3) dopamine receptor and Alpha-1D adrenergic receptor ligand... 1 0
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 2 9
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Substance-P receptor ligand SureCN7796965 family 9 1
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Neuromedin-K receptor and Potassium voltage-gated channel subf... 13 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Motilin receptor ligand SureCN2768052 family 3 0
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
Translocator protein inhibitor 2-(7-Chloro-5-methyl-4-oxo-3-ph... 1 0
Histamine H3 receptor ligand SureCN3542210 family 1 0
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN3553433 family 22 0
Glycogen phosphorylase, liver form inhibitor 2-[(1R,2R)-2-[(5-... 3 2
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
Serine/threonine-protein kinase pim-1 and Calcium/calmodulin-d... 1 0
Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-... 2 3
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
Endothelin-converting enzyme 1 inhibitor 5-(3,3-dimethylbutano... 1 1
Histone deacetylase 1 and HD2 type histone deacetylase HDA106 ... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27277 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543