CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18053
Family Name Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07R6AO family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00307808 Functional Category Bioactive
Superfamily Aurora kinase A and Receptor-type tyrosine-protein kinase FLT3 Binder Superfamily
Class Class 1144

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
Rho-associated protein kinase 2 inhibitor SureCN13457044 family 1 17
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 3
Receptor-type tyrosine-protein kinase FLT3 ligand 2-(6,7-dimet... 3 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... 1 0
Platelet-derived growth factor receptor beta and Macrophage co... 1 0
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 4 2
Deoxycytidine kinase inhibitor 2-[5-[4-[(4,6-diaminopyrimidin-... 14 11
Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclop... 1 2
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 2 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 2
Protein kinase C theta type and Tyrosine-protein kinase Lyn in... 2 1
Glucokinase inhibitor AGN-PC-03ZE4O family 4 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00445653 CHEMBL499623 Bioactive AGN-PC-077PZ7

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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