CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18153
Family Name Collagenase 3 inhibitor MMP-13 Inhibitor family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00445976 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 12 Inhibitor SB681323 Superfamily
Class Class 824

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Prothrombin Inhibitor Dabigatran Family 7 182
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 4 14
Sphingosine 1-phosphate receptor 5 and Sphingosine 1-phosphate... 2 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
C-C chemokine receptor type 5 ligand N-[3-[4-[3-cyclohexyl-5-(... 5 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 1 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00445976 CHEMBL514794 Bioactive MMP-13 Inhibitor

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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