CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1817
Family Name Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-aminobutyric acid receptor subunit beta-3 ligand SureCN2646664 family
No. of Seeds 31 No. of Other Members 11
Family Centroid CFAMM00168547 Functional Category Bioactive
Superfamily Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-aminobutyric acid receptor subunit gamma-2 Ligand TPA-023 Superfamily
Class Class 855

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GSK561679 Family 5 6
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Ibrutinib family 2 27
PF-02545920 family 16 140
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
Platelet-derived growth factor receptor beta and Ephrin type-B... 9 16
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Oxytocin receptor and Vasopressin V1a receptor Ligand PF-32741... 4 36
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
Xanthine dehydrogenase/oxidase inhibitor AGN-PC-00KCTP family 3 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CC4... 20 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 6
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 10 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 6 6
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 4 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 12 8
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Leukotriene B4 receptor 1 ligand AGN-PC-075N6M family 2 4
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 4
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 3 4
Sodium/glucose cotransporter 2 inhibitor AGN-PC-0A9TPG family 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 6 0
Voltage-dependent calcium channel subunit alpha-2/delta-1 and ... 9 15
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Corticotropin-releasing factor receptor 1 ligand CHEMBL1819076... 2 0
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
Corticotropin-releasing factor receptor 1 ligand CHEMBL1830528... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Metabotropic glutamate receptor 5 ligand SureCN4297614 family 2 5
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-... 3 2
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 7 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0
Metabotropic glutamate receptor 2 ligand 8-chloro-3-(cycloprop... 6 2
Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S... 6 1
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 7 1
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 4 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-07... 1 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Type-1 angiotensin II receptor ligand AGN-PC-00FH82 family 1 1
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN136... 1 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Hepatocyte growth factor receptor and Potassium voltage-gated ... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor AGN-PC... 2 0
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00327751 CHEMBL179474 Bioactive SureCN2652950
CFAMM00327757 CHEMBL300862 Bioactive 3-phenyl-6-(pyrazin-2-ylmethoxy)-[1,2,4]triazolo[3,4-a]phthalazine
CFAMM00327750 CHEMBL179414 Bioactive SureCN2647571
CFAMM00327756 CHEMBL300615 Bioactive AGN-PC-0055ZY
CFAMM00327748 CHEMBL178677 Bioactive AGN-PC-008HPH
CFAMM00327741 CHEMBL179558 Bioactive AGN-PC-004HRT
CFAMM00327754 CHEMBL296607 Bioactive 8-methyl-3-phenyl-6-(pyridin-2-ylmethoxy)-[1,2,4]triazolo[3,4-a]phthalazine
CFAMM00327760 CHEMBL362485 Bioactive AGN-PC-0089MN
CFAMM00327746 CHEMBL292462 Bioactive 3-(4-fluorophenyl)-6-(pyridin-2-ylmethoxy)-[1,2,4]triazolo[3,4-a]phthalazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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