CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18212
Family Name Acyl-CoA desaturase inhibitor SureCN1182546 family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00446119 Functional Category Bioactive
Superfamily Cytochrome P450 3A4 and Acyl-CoA desaturase Binder Superfamily
Class Class 2081

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
D(3) dopamine receptor Ligand PF-217830 Family 21 7
Smoothened homolog Inhibitor LDE225 Family 3 76
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
MK-6096 family 3 69
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(4-ethox... 4 5
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN2059024 f... 6 3
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Matrix metalloproteinase-9 and Collagenase 3 inhibitor 5-[4-(6... 1 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Microsomal triglyceride transfer protein large subunit inhibit... 9 0
Transient receptor potential cation channel subfamily V member... 2 4
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Renin and Cytochrome P450 3A4 inhibitor AGN-PC-046RG9 family 8 28
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Growth hormone secretagogue receptor type 1 and Muscarinic ace... 3 9
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00446115 CHEMBL522872 Bioactive 3-[6-(4-methoxyphenyl)-7-oxo-2-[[3-(trifluoromethyl)phenyl]methylamino]pteridin-8-yl]propanamide
CFAMM00446119 CHEMBL521993 Bioactive SureCN1182546

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27621 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543