CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18223
Family Name Dihydrofolate reductase and Bifunctional dihydrofolate reductase-thymidylate synthase inhibitor AGN-PC-04WXTO family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00446140 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Peptide deformylase, mitochondrial Binder Superfamily
Class Class 343

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Transient receptor potential cation channel subfamily V member... 15 457
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Peptide deformylase, mitochondrial Inhibitor 5-chloryl-2,4,6-q... 2 6
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Corticotropin-releasing factor receptor 1 ligand 5-(2,4-dichlo... 5 17
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 1
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
Vascular endothelial growth factor receptor 2 and Fibroblast g... 5 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 0
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00446140 CHEMBL522543 Bioactive AGN-PC-04WXTO

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26230 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543