CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18247
Family Name Neuronal acetylcholine receptor subunit alpha-4 and Neuronal acetylcholine receptor subunit alpha-7 ligand CHEMBL525735 family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00446195 Functional Category Bioactive
Superfamily Platelet-activating factor receptor and Histamine H3 receptor Binder Superfamily
Class Class 1491

Cousin Family NamesSeedsMembers
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Amrino... 3 55
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Substance-P receptor Ligand TAK-637 Family 18 63
Amg 423 family 7 47
ABC294640 family 5 75
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 4
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Histamine H3 receptor ligand SureCN1857507 family 1 4
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Histamine H3 receptor ligand (4-propan-2-yl-1,4-diazepan-1-yl)... 1 0
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
DNA gyrase subunit A and DNA gyrase subunit B inhibitor AGN-PC... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00446195 CHEMBL525735 Bioactive CHEMBL525735

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

25238 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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