CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18257
Family Name 5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine receptor 3C ligand CHEMBL52772 family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00446226 Functional Category Bioactive
Superfamily Beta-lactamase and GABA theta subunit Binder Superfamily
Class Class 3430

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thi... 3 36
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 14 Inhibitor 9-benzyl-6-pheny... 5 33
Metabotropic glutamate receptor 5 Ligand 2-methyl-4-(pyridin-3... 10 35
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Metabotropic glutamate receptor 5 Ligand N-[4-(3-pyridylethyny... 2 10
Metabotropic glutamate receptor 5 Ligand 4-(4-chlorophenylthio... 4 17
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(naphthalen-1-yl)-4-neo... 5 78
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 3 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Histamine H3 receptor Ligand 2-(1,4'-bipiperidin-1'-yl)thiazol... 2 23
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Amine oxidase [flavin-containing] B Inhibitor 2-(2-cyclohexyli... 6 44
D(2) dopamine receptor Ligand PD-135146 Family 5 11
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Reverse transcriptase Inhibitor 1-benzothiazol-2-yl-3-phenethy... 2 19
NADH-ubiquinone oxidoreductase chain 3 Inhibitor 6-thiophen-3-... 2 0
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 20
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 2 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Neuropeptide Y receptor type 5 and Potassium voltage-gated cha... 2 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
5-hydroxytryptamine receptor 6 ligand 6-chloro-5-[1-(1-methylp... 9 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Inosine-5'-monophosphate dehydrogenase and Nuclear receptor RO... 2 9
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Cell division cycle 7-related protein kinase inhibitor AGN-PC-... 6 6
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Neuropeptide Y receptor type 5 ligand 2-fluoro-N-[5-[(4-pyridi... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-[2-[(4-mor... 2 3
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Cyclin-dependent kinase 6 and Cyclin-dependent kinase 4 inhibi... 1 0
Vascular endothelial growth factor receptor 2 ligand AC1NS6KN ... 4 5
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Methionine aminopeptidase 2 inhibitor SureCN5376630 family 1 0
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Tyrosine-protein kinase ITK/TSK and Tyrosine-protein kinase Lc... 2 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Trans-2-enoyl-ACP reductase II inhibitor AGN-PC-01LWZK family 3 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 3-(1-... 1 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Prostaglandin G/H synthase 2 inhibitor AGN-PC-00FW8Y family 1 1
Cytochrome P450 11B1, mitochondrial and Cytochrome P450 11B2, ... 1 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Corticotropin-releasing factor receptor 1 ligand 2-[1-[1-[4-ni... 2 1
Corticotropin-releasing factor receptor 1 ligand 2-[1-[1-(4-me... 5 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00446226 CHEMBL52772 Bioactive CHEMBL52772

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26822 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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