CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18286
Family Name B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[(E)-3-[6-(methylcarbamoyl)pyridin-3-yl]prop-2-enoyl]amino]acetyl]amino]-2-[(2-methylquinolin-8-yl)oxymethyl]benzene-1,3-dicarboxamide;dihydrochloride family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00446339 Functional Category Bioactive
Superfamily B2 bradykinin receptor Binder Superfamily
Class Class 297

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Smoothened homolog Inhibitor LDE225 Family 3 76
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
B2 bradykinin receptor Ligand FR-173657 Family 44 180
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
B2 bradykinin receptor ligand (E)-N-[2-[2,4-dimethoxy-N-methyl... 3 2
B2 bradykinin receptor ligand 2-(4-aminobutylcarbamoylamino)-N... 5 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Cysteinyl leukotriene receptor 1 ligand SureCN7808360 family 4 11
B2 bradykinin receptor ligand SureCN7012818 family 1 2
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
B2 bradykinin receptor ligand 4-[(E)-3-[[2-[2,4-dichloro-3-[[4... 29 2
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
B2 bradykinin receptor ligand SureCN8516699 family 3 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
B2 bradykinin receptor ligand SureCN6640854 family 7 4
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Inosine-5'-monophosphate dehydrogenase inhibitor SureCN1318237... 2 12
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QHF0 family 3 1
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940990 family 3 3
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
RAC-alpha serine/threonine-protein kinase inhibitor 6-[5-[(2S)... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 7-met... 3 2
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Inosine-5'-monophosphate dehydrogenase inhibitor 2-(2,3-dichlo... 2 0
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
B2 bradykinin receptor ligand AGN-PC-073GJI family 2 4
Collagenase 3 and Disintegrin and metalloproteinase domain-con... 1 2
B2 bradykinin receptor ligand SureCN7976932 family 2 0
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 3
Substance-P receptor ligand SureCN2139814 family 7 7
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
B2 bradykinin receptor ligand (E)-N-[2-[N-methyl-3-[(2-methylq... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 1
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Serine/threonine-protein kinase Chk1 inhibitor 9-(1-methylpyrr... 1 1
B2 bradykinin receptor ligand (E)-N-[2-[N-methyl-3-[(2-methylq... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Prothrombin inhibitor AGN-PC-074I2Z family 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00446339 CHEMBL538784 Bioactive 1-N,3-N-dimethyl-4-[methyl-[2-[[(E)-3-[6-(methylcarbamoyl)pyridin-3-yl]prop-2-enoyl]amino]acetyl]amino]-2-[(2-methylquinolin-8-yl)oxymethyl]benzene-1,3-dicarboxamide;dihydrochloride
CFAMM00446338 CHEMBL555006 Bioactive 1-N,3-N-dimethyl-4-[2-[[[(E)-3-[6-(methylcarbamoyl)pyridin-3-yl]prop-2-enoyl]amino]methyl]pyrrol-1-yl]-2-[(2-methylquinolin-8-yl)oxymethyl]benzene-1,3-dicarboxamide;dihydrochloride
CFAMM00446337 CHEMBL537683 Bioactive 4-[2-[[[(E)-3-[4-(dimethylcarbamoyl)phenyl]prop-2-enoyl]amino]methyl]pyrrol-1-yl]-1-N,1-N,3-N,3-N-tetramethyl-2-[(2-methylquinolin-8-yl)oxymethyl]benzene-1,3-dicarboxamide;hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26844 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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