CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1830
Family Name Aurora kinase A and Aurora kinase B inhibitor 3uol family
No. of Seeds 6 No. of Other Members 5
Family Centroid CFAMM00162876 Functional Category Bioactive
Superfamily D(4) dopamine receptor Ligand L-745,870 Superfamily
Class Class 1567

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
RAC-gamma serine/threonine-protein kinase and Ribosomal protei... 3 5
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
HER Inhibitor AC480 Family 4 67
Vascular endothelial growth factor receptor 2 Ligand Ptk787/zk... 5 38
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Aurora kinase A Inhibitor ABT-348 Family 20 49
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Histamine H3 receptor Ligand SCH79687 Family 11 29
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 2
Xanthine dehydrogenase/oxidase inhibitor AGN-PC-06VJIZ family 1 2
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Adenosine receptor A3 ligand AGN-PC-07N4XX family 6 10
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Epidermal growth factor receptor and Tyrosine-protein kinase A... 4 3
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
Adenosine receptor A3 ligand 5-butyl-8-(4-methylsulfanylphenyl... 2 4
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Adenosine receptor A3 ligand SureCN6627522 family 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Cellular tumor antigen p53 inhibitor CHEMBL1318500 family 1 0
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
3-phosphoinositide-dependent protein kinase 1 and Rho-associat... 12 11
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 5-[4-... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 9 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 1
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 1 0
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidaz... 4 1
Cyclin-dependent kinase 2 and MAP kinase-activated protein kin... 3 0
Sigma non-opioid intracellular receptor 1 ligand 1-(3,4-dichlo... 2 19
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 4 8
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-chloro... 2 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 8
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Casein kinase II subunit alpha inhibitor N-[2-chloro-5-[[3-cya... 2 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 9 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
ALK tyrosine kinase receptor ligand 3-[1-[(3-fluorophenyl)meth... 2 0
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 6 6
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
High affinity nerve growth factor receptor ligand SureCN333709... 4 5
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 26
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Serine/threonine-protein kinase PLK1 inhibitor 2-amino-pyrazol... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00327905 CHEMBL256205 Bioactive 1-[4-(3-amino-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-(3-chloro-4-fluorophenyl)urea
CFAMM00327898 CHEMBL121796 Bioactive AC1NS36Z
CFAMM00327903 CHEMBL255746 Bioactive 1-[4-(3-amino-2H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-3-(3-chlorophenyl)urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27510 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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