CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18304
Family Name 5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-piperidin-1-ylethyl)-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylquinoline-3-carboxamide family
No. of Seeds 13 No. of Other Members 5
Family Centroid CFAMM00446416 Functional Category Bioactive with Natural Product
Superfamily Beta-lactamase and Cannabinoid receptor 2 Binder Superfamily 2
Class Class 4779

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
5-hydroxytryptamine receptor 4 Ligand TD-5108 Family 21 24
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Androgen receptor Ligand LG-121071 Family 8 32
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Transient receptor potential cation channel subfamily V member... 6 33
Androgen receptor Ligand 6-n-propyl -4-trifluoromethylquinolin... 29 13
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Amine oxidase [flavin-containing] B Inhibitor L-136662 Family 3 20
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand methy... 2 11
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 3 3
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 5 14
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 6
Neuropeptide S receptor ligand AGN-PC-071SSH family 1 6
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 11 9
Neuropeptide Y receptor type 5 ligand 2-(5-fluoro-2,3-dihydroi... 4 3
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 1 2
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(5-nitro-2,3-dihyd... 2 6
Dipeptidyl peptidase 4 inhibitor 4-[4-[(3S,5S)-5-(1,3-thiazoli... 3 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
Histamine H3 receptor and Histamine receptor H3 ligand 1-cyclo... 3 4
Histamine receptor H3 ligand N-[2-methyl-4-[(3S)-3-[(2S)-2-met... 10 7
Histamine receptor H3 ligand N-[2-methyl-4-[(3S)-3-[(2S)-2-met... 1 0
Histamine receptor H3 ligand N-[4-[3-(2-methylpyrrolidin-1-yl)... 2 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 2
Dipeptidyl peptidase 4 inhibitor 4-[[(3S,5S)-5-[(2S)-2-cyanopy... 4 12
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 5
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
Metabotropic glutamate receptor 2 ligand 4-[4-(methylamino)phe... 1 4
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00446422 CHEMBL538956 Bioactive ethyl 4-[7-[(1R,5S)-3-[(2-oxo-1-propan-2-ylquinoline-3-carbonyl)amino]-8-azabicyclo[3.2.1]octan-8-yl]heptyl]piperazine-1-carboxylate
CFAMM00446415 CHEMBL558719 Bioactive 2-oxo-N-[(1R,5S)-8-(5-piperidin-1-ylpentyl)-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylquinoline-3-carboxamide
CFAMM00446421 CHEMBL538706 Bioactive 2-oxo-N-[(1R,5S)-8-(8-piperidin-1-yloctyl)-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylquinoline-3-carboxamide
CFAMM00446413 CHEMBL558855 Bioactive N-[(1R,5S)-8-[3-[(2R)-2-carbamoylpyrrolidin-1-yl]propyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00446420 CHEMBL555222 Bioactive 2-oxo-N-[(1R,5S)-8-[3-(4-phenylpiperazin-1-yl)propyl]-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylquinoline-3-carboxamide
CFAMM00446412 CHEMBL539713 Bioactive N-[(1R,5S)-8-[7-[(2R)-2-carbamoylpyrrolidin-1-yl]heptyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00446426 CHEMBL551013 Bioactive 2-oxo-N-[(1R,5S)-8-(7-piperidin-1-ylheptyl)-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylquinoline-3-carboxamide
CFAMM00446419 CHEMBL561398 Bioactive 2-oxo-N-[(1R,5S)-8-(3-piperidin-1-ylpropyl)-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylquinoline-3-carboxamide
CFAMM00446425 CHEMBL549650 Bioactive N-[(1R,5S)-8-(3-morpholin-4-ylpropyl)-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00446411 CHEMBL539651 Bioactive 2-oxo-N-[(1R,5S)-8-[7-(4-phenylpiperazin-1-yl)heptyl]-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylquinoline-3-carboxamide
CFAMM00446410 CHEMBL559322 Bioactive N-[(1R,5S)-8-(7-morpholin-4-ylheptyl)-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide
CFAMM00446417 CHEMBL540980 Bioactive ethyl 4-[3-[(1R,5S)-3-[(2-oxo-1-propan-2-ylquinoline-3-carbonyl)amino]-8-azabicyclo[3.2.1]octan-8-yl]propyl]piperazine-1-carboxylate
CFAMM00446416 CHEMBL558259 Bioactive 2-oxo-N-[(1R,5S)-8-(2-piperidin-1-ylethyl)-8-azabicyclo[3.2.1]octan-3-yl]-1-propan-2-ylquinoline-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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