CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18337
Family Name Serine/threonine-protein kinase mTOR and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform inhibitor pyrazolo pyrimidine, 26 family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00169071 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase mTOR and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Binder Superfamily
Class Class 1233

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
HER Inhibitor AC480 Family 4 67
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
PHA848125 family 13 138
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Smoothened homolog Inhibitor LY2940680 Family 3 18
JAK Inhibitor Momelotinib Family 33 83
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Cartazo... 11 105
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Smoothened homolog inhibitor SureCN1091571 family 2 2
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Neuropeptide Y receptor type 5 ligand 3-pyridin-2-yl-8-[[(5-py... 2 0
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Serine/threonine-protein kinase B-raf inhibitor SureCN1013857 ... 9 3
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 4
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Renin inhibitor AGN-PC-073MLF family 7 6
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
Tyrosine-protein kinase SYK and Cytochrome P450 2D6 inhibitor ... 3 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-chloro... 2 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 12 3
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 9 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Tyrosine-protein kinase JAK2 inhibitor N,N-dimethyl-4-[[8-(4-m... 2 1
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 1
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 13
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Glucocorticoid receptor ligand N-[2-[[[5-amino-1-(4-fluorophen... 1 0
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00446788 CHEMBL576768 Bioactive pyrazolo pyrimidine, 5v

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27273 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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