CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18340
Family Name Growth hormone-releasing hormone receptor ligand (1S)-1'-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-5-phenylpentanoyl]spiro[1,2-dihydroindene-3,4'-piperidine]-1-carboxylic acid;hydrochloride family
No. of Seeds 7 No. of Other Members 4
Family Centroid CFAMM00446801 Functional Category Bioactive with Natural Product
Superfamily Integrin beta-1 and Integrin alpha-4 Binder Superfamily 23
Class Class 4613

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Dopamine reuptake Inhibitor Amineptine Family 2 5
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Neuromedin-K receptor Ligand Senktide Family 15 22
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Caspase-1 inhibitor (3S)-3-[[(2S)-4-(2-naphthalen-1-ylethylami... 1 0
Tryptase alpha/beta-1 inhibitor methyl 3-[3-(aminomethyl)pheny... 1 3
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 4 7
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 1
Neurotensin receptor type 1 and Retinal dehydrogenase 1 ligand... 1 19
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-1-[... 8 0
Chymase and Chymotrypsinogen B inhibitor AGN-PC-075LTI family 2 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Calpain-1 catalytic subunit inhibitor Peptidyl alpha-Ketoacid,... 1 0
Histamine H3 receptor ligand Conessine analogue, 13e family 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 7 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 2-[(1... 4 0
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00446796 CHEMBL540805 Bioactive 2-[(1R)-1'-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-5-phenylpentanoyl]spiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]acetic acid;hydrochloride
CFAMM00446802 CHEMBL553478 Bioactive 2-[(1S)-1'-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-5-phenylpentanoyl]spiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]acetic acid;hydrochloride
CFAMM00446795 CHEMBL540800 Bioactive 3-[1'-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-5-phenylpentanoyl]spiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]propanoic acid;hydrochloride
CFAMM00446801 CHEMBL545704 Bioactive (1S)-1'-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-5-phenylpentanoyl]spiro[1,2-dihydroindene-3,4'-piperidine]-1-carboxylic acid;hydrochloride
CFAMM00446792 CHEMBL545465 Bioactive ethyl (1S)-1'-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-5-phenylpentanoyl]spiro[1,2-dihydroindene-3,4'-piperidine]-1-carboxylate;hydrochloride
CFAMM00446798 CHEMBL544769 Bioactive ethyl (1R)-1'-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-5-phenylpentanoyl]spiro[1,2-dihydroindene-3,4'-piperidine]-1-carboxylate;hydrochloride
CFAMM00446797 CHEMBL553290 Bioactive (1R)-1'-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-5-phenylpentanoyl]spiro[1,2-dihydroindene-3,4'-piperidine]-1-carboxylic acid;hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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