CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1835
Family Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha and Protein farnesyltransferase subunit beta inhibitor SureCN6775081 family
No. of Seeds 13 No. of Other Members 0
Family Centroid CFAMM00327941 Functional Category Bioactive
Superfamily Beta-3 adrenergic receptor and Pol polyprotein Binder Superfamily
Class Class 630

Cousin Family NamesSeedsMembers
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Renin Inhibitor CP-305202 Family 9 30
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
B2 bradykinin receptor ligand SureCN7012818 family 1 2
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Caspase-1 inhibitor (3S)-3-[[2-[3-(naphthalene-2-carbonylamino... 1 0
Beta-1 adrenergic receptor and Beta-3 adrenergic receptor liga... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Pol polyprotein inhibitor Tertiary Amide deriv. 58 family 1 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 1
Leukotriene A-4 hydrolase inhibitor SureCN3030546 family 9 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 7 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Potassium voltage-gated channel subfamily A member 5 ligand AG... 1 0


External ID

Functional Category

Molecule Name

CFAMM00327949 CHEMBL164480 Bioactive (2S)-2-[[4-[(E)-2-[4-[(3,5-difluorophenyl)methoxy]pyridin-3-yl]ethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00327939 CHEMBL132645 Bioactive SureCN6777701
CFAMM00327945 CHEMBL331521 Bioactive SureCN6777610
CFAMM00327948 CHEMBL336327 Bioactive SureCN6771420
CFAMM00327938 CHEMBL274122 Bioactive SureCN6775626
CFAMM00327944 CHEMBL134726 Bioactive SureCN7605005
CFAMM00327947 CHEMBL133370 Bioactive SureCN6778157
CFAMM00327937 CHEMBL135446 Bioactive SureCN6778228
CFAMM00327943 CHEMBL122086 Bioactive SureCN6776225
CFAMM00327946 CHEMBL335064 Bioactive SureCN6776600
CFAMM00327942 CHEMBL134396 Bioactive SureCN7605678
CFAMM00327941 CHEMBL122362 Bioactive SureCN6775081
CFAMM00327940 CHEMBL121863 Bioactive SureCN6777374

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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