CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18363
Family Name Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptamine receptor 2C ligand AGN-PC-07C0AS family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00153732 Functional Category Bioactive
Superfamily Sigma non-opioid intracellular receptor 1 and Histamine H3 receptor Binder Superfamily
Class Class 3413

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Substance-P receptor Ligand Ezlopitant Family 10 207
Dapoxetine family 3 40
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... 17 24
C-C chemokine receptor type 5 Ligand N-(2-(4-chlorobenzyloxy)-... 3 13
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI Inhibitor 2... 1 9
D(4) dopamine receptor ligand AGN-PC-0073PO family 7 10
Sigma non-opioid intracellular receptor 1 and 3-beta-hydroxyst... 15 11
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 7 0
Regulator of G-protein signaling 12 and Beta-lactamase inhibit... 1 7
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sodium-dependent serotonin transporter and Sodium-dependent no... 6 21
Nitric oxide synthase, inducible and Cytochrome P450 2D6 inhib... 2 1
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-(4-methoxyphenox... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-(4-... 2 6
Histamine H1 receptor and C-C chemokine receptor type 3 ligand... 2 2
Histamine H3 receptor ligand AGN-PC-0765YW family 1 4
Sodium-dependent noradrenaline transporter and Sodium-dependen... 14 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sigma non-opioid intracellular receptor 1 ligand 4-[[1-[(2-bro... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Kappa-type opioid receptor ligand AGN-PC-03TFVP family 1 10
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Growth hormone secretagogue receptor type 1 ligand N-benzyl-2-... 5 19
D(4) dopamine receptor ligand 4-[(4-chlorophenyl)methyl]-2-[(2... 1 0
Voltage-dependent T-type calcium channel subunit alpha-1G and ... 1 3
Histamine H3 receptor and Histamine H1 receptor ligand (NE)-N-... 1 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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