CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1838
Family Name Type-1 angiotensin II receptor and Type-2 angiotensin II receptor ligand SureCN9308852 family
No. of Seeds 10 No. of Other Members 54
Family Centroid CFAMM00327987 Functional Category Bioactive
Superfamily Type-1 angiotensin II receptor and Type-2 angiotensin II receptor Binder Superfamily 4
Class Class 1097

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 3 7
Thromboxane A2 receptor ligand SureCN9045130 family 4 32
Thromboxane A2 receptor ligand AC1NSKJR family 13 42
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 7 0
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Cytochrome P450 26A1 and Cytochrome P450 3A4 inhibitor 3-[6-[(... 14 26
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 29
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 1
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 4 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Coagulation factor X and Cationic trypsin inhibitor 2-[3-(diam... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Peroxisome proliferator-activated receptor gamma ligand (2S)-2... 8 0
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Prostaglandin D2 receptor 2 ligand AGN-PC-07C6PH family 1 0
Type-1 angiotensin II receptor and Endothelin-1 receptor ligan... 2 3
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00327998 CHEMBL124541 Bioactive SureCN9308130
CFAMM00327977 CHEMBL122212 Bioactive {4-[(2-ethyl-5,7-dimethyl-3h-imidazo[4,5-b]pyridin-3-yl)methyl]-2,6-dipropylphenoxy}(phenyl)acetic acid
CFAMM00327990 CHEMBL340367 Bioactive AGN-PC-0752NS
CFAMM00328024 CHEMBL121891 Bioactive SureCN9308570
CFAMM00327987 CHEMBL122224 Bioactive SureCN9308852
CFAMM00327967 CHEMBL122367 Bioactive AGN-PC-0752QC
CFAMM00328014 CHEMBL331797 Bioactive AGN-PC-0752SL
CFAMM00327992 CHEMBL40585 Bioactive AGN-PC-00OQPN
CFAMM00327999 CHEMBL15606 Bioactive 2-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenoxy]-2-(2-methylphenyl)acetic acid
CFAMM00328013 CHEMBL279103 Bioactive AGN-PC-02CFUM

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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