CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1841
Family Name Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand (E)-3-[4-[2-[methyl(2-phenylethyl)amino]-2-oxoethyl]-8-phenylmethoxynaphthalen-2-yl]prop-2-enoic acid family
No. of Seeds 10 No. of Other Members 8
Family Centroid CFAMM00328052 Functional Category Bioactive
Superfamily Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Binder Superfamily 2
Class Class 2290

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Histamine H1 receptor Ligand Doxepin Family 8 89
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Cholesteryl ester transfer protein Inhibitor Anacetrapib Family 3 63
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
P2X purinoceptor 3 Inhibitor A-317491 Family 1 2
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Histamine H3 receptor Ligand A-349821 Family 49 228
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 6 6
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Histamine H1 receptor ligand SureCN5064818 family 4 9
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745OX family 2 0
Caspase-1 inhibitor 5-(3-carbamoylnaphthalen-2-yl)oxy-3-[[(2S)... 1 11
Leukotriene B4 receptor 1 ligand AGN-PC-00GEAR family 2 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 4
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 12 0
Prostaglandin D2 receptor 2 ligand SureCN137334 family 1 0
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Prostaglandin E2 receptor EP4 subtype ligand 4-[(1S)-1-[[2-(tr... 2 1
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 1 1
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Free fatty acid receptor 1 ligand 3-[4-[[3-[2,6-dimethyl-4-[3-... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Estrogen receptor ligand 2-(3-hydroxy-6-oxoxanthen-9-yl)-5-[[4... 1 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 13 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
Estrogen receptor and Estrogen receptor beta ligand SureCN1450... 1 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 15 13
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
Androgen receptor and Estrogen receptor ligand estradiol benzo... 1 29
Estrogen receptor beta and Estrogen receptor ligand AGN-PC-074... 5 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 5
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Histamine H3 receptor ligand SureCN3945230 family 3 3
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 4 3
Metabotropic glutamate receptor 2 ligand SureCN787402 family 1 8
Prostaglandin E2 receptor EP4 subtype ligand SureCN4990561 family 2 2
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 1 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 2 1
Arachidonate 5-lipoxygenase and Arachidonate 15-lipoxygenase i... 1 2
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor SureCN807991... 1 1
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 4-[1-(adaman... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00328053 CHEMBL333493 Bioactive (2E,4E)-5-[4-[2-[methyl(2-phenylethyl)amino]-2-oxoethyl]-8-phenylmethoxynaphthalen-2-yl]penta-2,4-dienoic acid
CFAMM00328060 CHEMBL121959 Bioactive SureCN9023471
CFAMM00328052 CHEMBL125646 Bioactive (E)-3-[4-[2-[methyl(2-phenylethyl)amino]-2-oxoethyl]-8-phenylmethoxynaphthalen-2-yl]prop-2-enoic acid
CFAMM00328059 CHEMBL125128 Bioactive SureCN9023608
CFAMM00328051 CHEMBL328712 Bioactive 141835-49-6
CFAMM00328057 CHEMBL123486 Bioactive SureCN9023352
CFAMM00328050 CHEMBL126200 Bioactive 4-[2-[methyl(2-phenylethyl)amino]-2-oxoethyl]-8-pentoxynaphthalene-2-carboxylic acid
CFAMM00328049 CHEMBL419419 Bioactive 4-[2-[methyl(2-phenylethyl)amino]-2-oxoethyl]-8-phenoxynaphthalene-2-carboxylic acid
CFAMM00328055 CHEMBL122461 Bioactive 3-[4-[2-[methyl(2-phenylethyl)amino]-2-oxoethyl]-8-phenylmethoxynaphthalen-2-yl]propanoic acid
CFAMM00328047 CHEMBL125476 Bioactive (E)-3-[4-[2-[methyl(2-phenylethyl)amino]-2-oxoethyl]-8-phenoxynaphthalen-2-yl]prop-2-enoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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