CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18430
Family Name P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3-methylbutan-2-yl)-1-oxoisoquinolin-5-yl]acetamide family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00447420 Functional Category Bioactive
Superfamily P2X purinoceptor 7 and Muscleblind-like protein 1 Binder Superfamily
Class Class 1365

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Integrin beta-3 Inhibitor L-767679 Family 3 6
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Progesterone receptor Ligand 3-(3,3-dimethyl-2-oxoindolin-5-yl... 2 10
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 2
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 8
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 1-eth... 7 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 5
Cannabinoid receptor 2 ligand AGN-PC-087MPO family 7 21
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Mitogen-activated protein kinase 14 inhibitor 4-chloro-N-cyclo... 2 0
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-3-... 2 0
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Cannabinoid receptor 2 ligand AGN-PC-046LZ0 family 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 7 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 2
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Protein farnesyltransferase subunit beta and Protein farnesylt... 4 13


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00447420 CHEMBL550030 Bioactive 2-(1-adamantyl)-N-[2-(1-hydroxy-3-methylbutan-2-yl)-1-oxoisoquinolin-5-yl]acetamide
CFAMM00447422 CHEMBL551360 Bioactive 2-(1-adamantyl)-N-[2-(1,3-dihydroxypropan-2-yl)-1-oxoisoquinolin-5-yl]acetamide
CFAMM00447421 CHEMBL556680 Bioactive 2-(1-adamantyl)-N-[1-oxo-2-[[(2R)-pyrrolidin-2-yl]methyl]isoquinolin-5-yl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

44592 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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