CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18445
Family Name P2X purinoceptor 7 inhibitor 2-[4-chloro-3-(trifluoromethyl)phenyl]-N-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00447479 Functional Category Bioactive
Superfamily Survival motor neuron protein and Tankyrase-2 Binder Superfamily
Class Class 1375

Cousin Family NamesSeedsMembers
Rho-associated protein kinase 2 inhibitor N-(7-chloro-1-oxo-2H... 13 42
Mitogen-activated protein kinase 14 inhibitor 4-chloro-N-cyclo... 2 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
P2X purinoceptor 7 inhibitor (2S)-2-[5-[[2-(1-adamantyl)acetyl... 1 0
Acyl-CoA desaturase and Acyl-CoA desaturase 1 inhibitor SureCN... 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00447480 CHEMBL563255 Bioactive N-[6-chloro-2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]-2-[3-fluoro-4-(trifluoromethyl)phenyl]acetamide
CFAMM00447479 CHEMBL560219 Bioactive 2-[4-chloro-3-(trifluoromethyl)phenyl]-N-[2-(2-hydroxyethyl)-1-oxoisoquinolin-5-yl]acetamide
CFAMM00447478 CHEMBL564882 Bioactive N-(6-chloro-2-cyclopropyl-1-oxoisoquinolin-5-yl)-2-[2-fluoro-3-(trifluoromethyl)phenyl]acetamide
CFAMM00447477 CHEMBL550436 Bioactive 2-[4-chloro-3-(trifluoromethyl)phenyl]-N-[2-[(2R)-1-hydroxypropan-2-yl]-1-oxoisoquinolin-5-yl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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