CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18477
Family Name Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-04VNKY family
No. of Seeds 1 No. of Other Members 4
Family Centroid CFAMM00447612 Functional Category Bioactive
Superfamily Poly [ADP-ribose] polymerase 1 and Cellular tumor antigen p53 Binder Superfamily 2
Class Class 824

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
PHA848125 family 13 138
Smoothened homolog Inhibitor LY2940680 Family 3 18
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family 5 72
Metabotropic glutamate receptor 5 Ligand N-(1,4-diphenyl-1h-py... 3 35
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-py... 6 37
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 55
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Poly [ADP-ribose] polymerase 1 inhibitor 2-[2-[4-(1H-indazol-3... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-088VMM fa... 1 12
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Mitogen-activated protein kinase 14 inhibitor 3ocg family 6 0
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Corticotropin-releasing factor receptor 1 ligand 2-[6-(dimethy... 1 4
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 6 6
Mitogen-activated protein kinase 14 inhibitor SureCN294394 family 2 6
Glucocorticoid receptor ligand 5-amino-N-[(2R)-2-[[(2,6-dichlo... 6 5
Poly [ADP-ribose] polymerase 1 inhibitor SureCN6479420 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00447612 CHEMBL551854 Bioactive AGN-PC-04VNKY

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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