CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18522
Family Name Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (3R)-3-amino-1-[8-(pyridin-2-ylmethyl)-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00447900 Functional Category Bioactive
Superfamily chemokine receptor ligand Maraviroc, Dipeptidyl peptidase inhibitor superSitagliptin family
Class Class 214

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
C-C chemokine receptor type 5 Ligand Maraviroc Family 29 81
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Class II cytokine receptor Ligand IL-10 Family 7 45
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 16
Prothrombin inhibitor SureCN5855286 family 15 8
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Smoothened homolog inhibitor SureCN1091571 family 2 2
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(3,4-di... 3 1
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Calcitonin gene-related peptide type 1 receptor ligand SureCN2... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 2 10
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 3
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Cholecystokinin receptor type A ligand 6-[2-[2-(cyclohexylmeth... 2 6
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Renin inhibitor AGN-PC-073MLF family 7 6
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-[2-(trif... 1 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
C-C chemokine receptor type 5 ligand N-[3-[4-[3-cyclohexyl-5-(... 5 4
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (3... 2 0
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Renin inhibitor AGN-PC-002JXB family 14 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Type-1 angiotensin II receptor ligand 2-[(2-ethyl-5,7-dimethyl... 5 3
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cathepsin S and Cathepsin K inhibitor 2-cyano-N-[(2R)-1-phenyl... 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00447900 CHEMBL557176 Bioactive (3R)-3-amino-1-[8-(pyridin-2-ylmethyl)-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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