CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18566
Family Name Potassium voltage-gated channel subfamily H member 2 and D(3) dopamine receptor ligand 1-(3-chlorophenyl)-3-[2-[4-(4-chlorophenyl)piperidin-1-yl]ethyl]imidazolidin-2-one family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00305249 Functional Category Bioactive
Superfamily Dopamine receptor Ligand Domperidone Superfamily
Class Class 221

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Dopamine receptor Ligand Domperidone Family 2 21
Serotonin re-uptake inhibitor Dibenzazepine Clomipramine Family 2 23
Sigma non-opioid intracellular receptor 1 Ligand MS-377 Family 1 21
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-chloro-phenyl)... 5 50
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Cannabinoid receptor 1 Ligand 1-(bis(4-chlorophenyl)methyl)-3-... 4 44
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 34
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 4 18
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C8 inhib... 6 5
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 0
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 6 12
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 1
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 6
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Melanin-concentrating hormone receptor 1 ligand 3-(3-chloro-4-... 8 24
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Survival motor neuron protein and Retinal dehydrogenase 1 inhi... 1 1
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
C-C chemokine receptor type 2 and C-C chemokine receptor type ... 2 8
D(3) dopamine receptor and D(2) dopamine receptor ligand 3-[4-... 4 23
Melanin-concentrating hormone receptor 1 ligand 1-[[4-[4-(3-cy... 14 23
Melanin-concentrating hormone receptor 1 ligand 4-(4-chlorophe... 2 0
Melanin-concentrating hormone receptor 1 ligand SureCN3845324 ... 7 4
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
Regulator of G-protein signaling 4 and Regulator of G-protein ... 1 5
Melanin-concentrating hormone receptor 1 ligand SureCN14265866... 11 2
C-C chemokine receptor type 5 ligand AC1MHYGF family 3 2
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Inosine-5'-monophosphate dehydrogenase inhibitor 1-(3,4-dichlo... 1 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
Substance-P receptor and Mu-type opioid receptor ligand ethyl ... 1 0
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 4 0
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Kappa-type opioid receptor ligand AGN-PC-077Q4Y family 5 9
Urotensin-2 receptor and Cytochrome P450 2D6 ligand 2-[3,4-dic... 2 3
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 6,7-dichlo... 2 0
Kappa-type opioid receptor and Urotensin-2 receptor ligand 2-(... 5 1
Mu-type opioid receptor and Nociceptin receptor ligand SureCN8... 7 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Melanin-concentrating hormone receptor 1 ligand SureCN13451707... 3 1
Urotensin-2 receptor and Kappa-type opioid receptor ligand Sur... 2 0
Somatostatin receptor type 1 ligand AGN-PC-078XL4 family 2 0
Neuropeptide Y receptor type 5 ligand SureCN6214451 family 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 3 1
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 3
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 2 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 2 1
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
Melanin-concentrating hormone receptor 1 ligand N-[1-[3-(4-chl... 1 0
Sigma non-opioid intracellular receptor 1 and Sodium-dependent... 2 1
Glycogen phosphorylase, liver form inhibitor TCMDC-135759 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00448047 CHEMBL612075 Bioactive 1-(3,4-dichlorophenyl)-3-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1,3-diazinan-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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