CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18597
Family Name Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 family
No. of Seeds 2 No. of Other Members 18
Family Centroid CFAMM00448120 Functional Category Bioactive
Superfamily and Serine/threonine-protein kinase Sgk1 Binder Superfamily
Class Class 898

Cousin Family NamesSeedsMembers
Thymidylate synthase inhibitor pyrrotopyrimidine derivative Pe... 4 23
Type-1 angiotensin II receptor Ligand Candesartan Family 3 75
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Type-1 angiotensin II receptor Ligand Eprosartan Family 36 176
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Casein kinase II subunit alpha Inhibitor CX-4945 Family 1 7
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing... 2 1
Eluxadoline family 4 85
Dihydroorotate dehydrogenase Inhibitor Cinchoninic Acid Family 1 21
Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic... 2 44
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Protein farnesyltransferase subunit beta Inhibitor A-313326 Fa... 85 149
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 12
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Bombesin receptor subtype-3 ligand AGN-PC-07ZAKV family 13 23
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 1 1
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor AC1O... 18 10
NS5B protein inhibitor AC1NQMYG family 6 12
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 16 34
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 7 11
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 7 3
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Type-1 angiotensin II receptor ligand SureCN9527437 family 2 34
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 9
Poly [ADP-ribose] polymerase 1 inhibitor ethyl 4-(4-carbamoyl-... 2 15
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 44
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 4
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 1
Prostaglandin D2 receptor 2 ligand SureCN2215286 family 7 5
Dipeptidyl peptidase 4 inhibitor 3-[6-[(3R,4S)-3-amino-4-(2,4,... 3 7
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 3... 5 14
Platelet-activating factor receptor ligand SureCN7491834 family 28 15
NS5B protein inhibitor (2E)-1-cyclohexyl-2-(2-fluoro-4-oxocycl... 2 10
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
C-C chemokine receptor type 5 ligand SureCN13543564 family 10 3
NS5B protein inhibitor AC1NQMYP family 5 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 9 6
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 11 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 29
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Neuropeptide Y receptor type 5 ligand AGN-PC-07R6YQ family 7 7
Neuropeptide Y receptor type 5 ligand SureCN4170426 family 4 13
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 3-methyl-4... 15 14
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Lysine--tRNA ligase inhibitor 4-[[2-(2-piperazin-1-ylpyridin-4... 2 0
B1 bradykinin receptor ligand methyl 2-[4-[(1R)-1-[[3-[(2-cyan... 8 7
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
Type-1 angiotensin II receptor and Type-1A angiotensin II rece... 3 0
Type-1 angiotensin II receptor ligand 2-butyl-3-[[4-(2-carboxy... 1 7
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(1-propan-2-ylpyr... 5 6
Coagulation factor VII inhibitor 2-[2-[(1-aminoisoquinolin-6-y... 1 14
Glutamate receptor 1 and Glutamate receptor 2 ligand SureCN784... 2 7
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-[5-(6-chl... 2 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 6
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 3
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Thromboxane-A synthase inhibitor AGN-PC-00NE8C family 2 3
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Neuropeptide Y receptor type 5 ligand AGN-PC-077LX1 family 8 1
Type-1 angiotensin II receptor ligand 2-ethyl-4-[[4-[2-(2H-tet... 2 0
Type-1A angiotensin II receptor ligand 2-[4-[[2-butyl-5-(tert-... 1 0
Thromboxane-A synthase inhibitor SureCN11474904 family 1 6
Serine/threonine-protein kinase mTOR inhibitor 3-(cyclohexylme... 2 1
Mitogen-activated protein kinase kinase kinase 5 inhibitor 4-(... 2 0
Type-1 angiotensin II receptor ligand AGN-PC-025PHO family 3 21
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 10
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 0
AMP deaminase 3 inhibitor 4-(2-imidazo[2,1-f][1,2,4]triazin-7-... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Type-1B angiotensin II receptor ligand SureCN9310003 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00448120 CHEMBL564555 Bioactive SureCN3774571

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27074 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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