CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1860
Family Name Monocarboxylate transporter 1 inhibitor 3-methyl-1-(2-methylpropyl)-5-propan-2-ylsulfanyl-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione family
No. of Seeds 9 No. of Other Members 7
Family Centroid CFAMM00328294 Functional Category Bioactive
Superfamily Monocarboxylate transporter 1 and Flap endonuclease 1 Binder Superfamily
Class Class 3460

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase Chk1 Inhibitor AZD7762 Family 26 90
Gonadotropin-releasing hormone receptor Ligand TAK-013 Family 19 10
Flap endonuclease 1 and DNA repair protein complementing XP-G ... 2 0
Monocarboxylate transporter 1 and Cytochrome P450 2C9 inhibito... 9 0
Monocarboxylate transporter 1 and Cytochrome P450 2C9 inhibito... 1 0


External ID

Functional Category

Molecule Name

CFAMM00328290 CHEMBL377309 Bioactive 5-cyclohexylsulfanyl-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione
CFAMM00328303 CHEMBL383696 Bioactive 5-cyclopentylsulfanyl-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione
CFAMM00328302 CHEMBL380673 Bioactive 5-(azetidine-1-carbonyl)-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione
CFAMM00328294 CHEMBL206229 Bioactive 3-methyl-1-(2-methylpropyl)-5-propan-2-ylsulfanyl-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione
CFAMM00328301 CHEMBL1221551 Bioactive 5-(2,5-dihydropyrrole-1-carbonyl)-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione
CFAMM00328293 CHEMBL381098 Bioactive 5-ethylsulfanyl-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione
CFAMM00328292 CHEMBL205465 Bioactive 3-methyl-1-(2-methylpropyl)-5-(piperidine-1-carbonyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione
CFAMM00328299 CHEMBL383669 Bioactive AC1NR09G
CFAMM00328291 CHEMBL439871 Bioactive 5-(3-hydroxy-3-methylazetidine-1-carbonyl)-3-methyl-1-(2-methylpropyl)-6-[[2-(trifluoromethyl)phenyl]methyl]thieno[2,3-d]pyrimidine-2,4-dione

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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