CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18604
Family Name Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)-8-[bis(2-chlorophenyl)methyl]-3-pyrimidin-2-yl-8-azabicyclo[3.2.1]octane family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00448155 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 5 and Sodium channel protein type 1 subunit alpha Binder Superfamily
Class Class 2568

Cousin Family NamesSeedsMembers
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
Benzodiazepine receptor Ligand Midazolam Family 5 160
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
HCV NS4B protein Inhibitor Clemizole Family 2 43
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Metabotropic glutamate receptor 5 Ligand 5-(2-(3-chlorophenyl)... 2 13
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Neuronal acetylcholine receptor subunit alpha-2 and Neuronal a... 2 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Nitric oxide synthase, inducible inhibitor N-(3-chlorophenyl)-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00448155 CHEMBL565168 Bioactive (1S,5S)-8-[bis(2-chlorophenyl)methyl]-3-pyrimidin-2-yl-8-azabicyclo[3.2.1]octane

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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