CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18608
Family Name P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-(2-aminoethyl)piperidin-1-yl]-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid family
No. of Seeds 17 No. of Other Members 2
Family Centroid CFAMM00448221 Functional Category Bioactive
Superfamily P2Y purinoceptor 12 Binder Superfamily 3
Class Class 639

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Saquinavir Family 64 428
Folate receptor gamma Ligand Folic Acid Family 4 100
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 11
Cholecystokinin receptor type A ligand A-65186 family 2 6
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 11
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 1
Folylpolyglutamate synthase, mitochondrial and Dihydrofolate r... 3 0
Dihydrofolate reductase inhibitor 2-[[4-[2-(2-amino-4-oxo-1,5,... 2 0
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-[3-(dimethylamino)... 106 49
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
P2Y purinoceptor 12 inhibitor (4S)-4-[(4,6-diphenylpyridine-2-... 1 0
P2Y purinoceptor 12 inhibitor (4S)-4-[[6-[4-[2-(methylamino)-2... 51 8
P2Y purinoceptor 12 inhibitor (4S)-5-oxo-5-(4-pentoxycarbonylp... 5 0
P2Y purinoceptor 12 inhibitor pentyl 4-[(2S)-5-[(2-methylpropa... 18 0
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-(4-amino-... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00448204 CHEMBL568384 Bioactive (4S)-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)-4-[[4-phenyl-6-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]pyrimidine-2-carbonyl]amino]pentanoic acid
CFAMM00448217 CHEMBL565573 Bioactive (4S)-4-[[4-[4-(2-hydroxyethoxy)piperidin-1-yl]-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448210 CHEMBL568257 Bioactive (4S)-4-[[4-(2-methoxyethylamino)-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448216 CHEMBL565300 Bioactive (4S)-4-[[4-(4-methoxypiperidin-1-yl)-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448209 CHEMBL566176 Bioactive (4S)-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)-4-[[4-phenyl-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyrimidine-2-carbonyl]amino]pentanoic acid
CFAMM00448222 CHEMBL567050 Bioactive (4S)-4-[[4-[4-(aminomethyl)piperidin-1-yl]-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448215 CHEMBL570156 Bioactive (4S)-4-[[4-[4-(2-methoxyethoxy)piperidin-1-yl]-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448208 CHEMBL571583 Bioactive (4S)-4-[[4-(4-aminopiperidin-1-yl)-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448221 CHEMBL566613 Bioactive (4S)-4-[[4-[4-(2-aminoethyl)piperidin-1-yl]-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448207 CHEMBL565542 Bioactive (4S)-4-[[4-(4-morpholin-4-ylpiperidin-1-yl)-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448220 CHEMBL570384 Bioactive (4S)-4-[[4-[4-(2-methoxyethoxymethyl)piperidin-1-yl]-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448213 CHEMBL567772 Bioactive (4S)-4-[[4-[4-(diethylcarbamoyl)piperidin-1-yl]-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448206 CHEMBL570271 Bioactive (4S)-4-[[4-[4-(2-methoxyethyl)piperidin-1-yl]-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448219 CHEMBL570285 Bioactive (4S)-4-[[4-(4-carbamoylpiperidin-1-yl)-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448212 CHEMBL570150 Bioactive (4S)-4-[[4-(4-carbamoylpiperazin-1-yl)-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448218 CHEMBL570388 Bioactive (4S)-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)-4-[[4-phenyl-6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]pyrimidine-2-carbonyl]amino]pentanoic acid
CFAMM00448211 CHEMBL570053 Bioactive (4S)-4-[[4-[4-[2-(dimethylamino)-2-oxoethyl]piperazin-1-yl]-6-phenylpyrimidine-2-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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