CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18613
Family Name P2Y purinoceptor 12 inhibitor (4S)-4-[[6-[4-[2-(methylamino)-2-oxoethyl]piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid family
No. of Seeds 51 No. of Other Members 8
Family Centroid CFAMM00448292 Functional Category Bioactive
Superfamily P2Y purinoceptor 12 Binder Superfamily 3
Class Class 639

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Saquinavir Family 64 428
Folate receptor gamma Ligand Folic Acid Family 4 100
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
GDC-0349 family 44 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 11
Cholecystokinin receptor type A ligand A-65186 family 2 6
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 11
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Thymidylate synthase inhibitor AGN-PC-0757PM family 1 0
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 1
Folylpolyglutamate synthase, mitochondrial and Dihydrofolate r... 3 0
Dihydrofolate reductase inhibitor 2-[[4-[2-(2-amino-4-oxo-1,5,... 2 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-[3-(dimethylamino)... 106 49
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
P2Y purinoceptor 12 inhibitor (4S)-4-[(4,6-diphenylpyridine-2-... 1 0
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-(2-aminoethyl)pipe... 17 2
P2Y purinoceptor 12 inhibitor (4S)-5-oxo-5-(4-pentoxycarbonylp... 5 0
P2Y purinoceptor 12 inhibitor pentyl 4-[(2S)-5-[(2-methylpropa... 18 0
Diacylglycerol O-acyltransferase 1 inhibitor 2-[4-[4-(4-amino-... 2 3
Thymidylate synthase and Dihydrofolate reductase inhibitor (2S... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00448266 CHEMBL567271 Bioactive (4S)-4-[[6-[4-[2-(dimethylamino)ethyl]piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448279 CHEMBL570153 Bioactive (4S)-4-[[6-[4-(ethylaminomethyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448292 CHEMBL565409 Bioactive (4S)-4-[[6-[4-[2-(methylamino)-2-oxoethyl]piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448305 CHEMBL570064 Bioactive (4S)-5-(4-butoxycarbonylpiperazin-1-yl)-5-oxo-4-[[2-phenyl-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyrimidine-4-carbonyl]amino]pentanoic acid
CFAMM00448318 CHEMBL567883 Bioactive (4S)-4-[[6-(4-methoxypiperidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448285 CHEMBL567280 Bioactive (4S)-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)-4-[[2-phenyl-6-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]pyrimidine-4-carbonyl]amino]pentanoic acid
CFAMM00448311 CHEMBL566745 Bioactive (4S)-4-[[6-(3-ethoxyazetidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448265 CHEMBL565363 Bioactive (4S)-5-oxo-4-[[6-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448278 CHEMBL570154 Bioactive (4S)-4-[[6-[4-(2-aminoethyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448291 CHEMBL569629 Bioactive (4S)-4-[[6-(4-acetylpiperazin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448304 CHEMBL571599 Bioactive (4S)-4-[[6-[4-[2-(azetidin-1-yl)-2-oxoethyl]piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448317 CHEMBL566520 Bioactive (4S)-4-[[6-(3-hydroxyazetidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448271 CHEMBL570385 Bioactive (4S)-4-[[6-(4-carbamoylpiperidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448284 CHEMBL568059 Bioactive (4S)-4-[[6-(4-aminopiperidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448297 CHEMBL567416 Bioactive (4S)-4-[[6-[4-(methylaminomethyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448264 CHEMBL565470 Bioactive (4S)-4-[[6-(4-methylpiperazin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448277 CHEMBL570155 Bioactive (4S)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[6-(4-methoxypiperidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxopentanoic acid
CFAMM00448290 CHEMBL569988 Bioactive (4S)-4-[[6-[4-(dimethylcarbamoyl)piperazin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448316 CHEMBL570289 Bioactive (4S)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[6-[4-(dimethylcarbamoyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxopentanoic acid
CFAMM00448270 CHEMBL567740 Bioactive (4S)-4-[[6-[4-(ethylcarbamoyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448283 CHEMBL567468 Bioactive (4S)-4-[[6-[4-(methoxymethyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448296 CHEMBL566599 Bioactive (4S)-4-[[6-(4-morpholin-4-ylpiperidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448309 CHEMBL565836 Bioactive (4S)-4-[[6-[4-[2-(ethylamino)-2-oxoethyl]piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448263 CHEMBL567064 Bioactive (4S)-4-[[6-[4-(2-methoxyethoxy)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448276 CHEMBL567915 Bioactive (4S)-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)-4-[[2-phenyl-6-[4-(pyrrolidin-1-ylmethyl)piperidin-1-yl]pyrimidine-4-carbonyl]amino]pentanoic acid
CFAMM00448289 CHEMBL567133 Bioactive (4S)-5-(4-butoxycarbonylpiperazin-1-yl)-5-oxo-4-[[2-phenyl-6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]pyrimidine-4-carbonyl]amino]pentanoic acid
CFAMM00448315 CHEMBL570045 Bioactive (4S)-4-[[6-[4-[2-(dimethylamino)-2-oxoethyl]piperazin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448269 CHEMBL570387 Bioactive (4S)-4-[[6-[4-(diethylcarbamoyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448282 CHEMBL567189 Bioactive (4S)-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)-4-[[2-phenyl-6-(pyrrolidin-3-ylmethylamino)pyrimidine-4-carbonyl]amino]pentanoic acid
CFAMM00448295 CHEMBL568211 Bioactive (4S)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[6-[4-(diethylcarbamoyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxopentanoic acid
CFAMM00448308 CHEMBL569742 Bioactive (4S)-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)-4-[[2-phenyl-6-[(1-propan-2-ylpiperidin-4-yl)amino]pyrimidine-4-carbonyl]amino]pentanoic acid
CFAMM00448275 CHEMBL565974 Bioactive (4S)-4-[[6-[4-(diethylaminomethyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448288 CHEMBL566913 Bioactive (4S)-4-[[6-[4-(azetidine-1-carbonyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448268 CHEMBL570386 Bioactive (4S)-4-[[6-[4-(dimethylcarbamoyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448314 CHEMBL570128 Bioactive (4S)-4-[[6-(4-carbamoylpiperazin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448294 CHEMBL570423 Bioactive (4S)-4-[[6-(2-hydroxyethylsulfanyl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448281 CHEMBL570151 Bioactive (4S)-5-oxo-4-[[6-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448261 CHEMBL567561 Bioactive (4S)-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)-4-[[2-phenyl-6-[4-(pyrrolidine-1-carbonyl)piperidin-1-yl]pyrimidine-4-carbonyl]amino]pentanoic acid
CFAMM00448274 CHEMBL570256 Bioactive (4S)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[6-[4-(2-methoxyethyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxopentanoic acid
CFAMM00448287 CHEMBL571929 Bioactive (4S)-4-[[6-(4-methylpiperidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448300 CHEMBL569914 Bioactive (4S)-4-[(6-morpholin-4-yl-2-phenylpyrimidine-4-carbonyl)amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448313 CHEMBL569995 Bioactive (4S)-5-(4-butoxycarbonylpiperazin-1-yl)-4-[[6-(4-morpholin-4-ylpiperidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino]-5-oxopentanoic acid
CFAMM00448267 CHEMBL570028 Bioactive (4S)-4-[[6-[4-(2-methoxyethyl)piperazin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448280 CHEMBL570152 Bioactive (4S)-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)-4-[[2-phenyl-6-(4-pyrrolidin-1-ylpiperidin-1-yl)pyrimidine-4-carbonyl]amino]pentanoic acid
CFAMM00448293 CHEMBL570275 Bioactive (4S)-5-oxo-4-[[6-[4-[(2-oxopyrrolidin-1-yl)methyl]piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448306 CHEMBL567709 Bioactive (4S)-4-[[6-[4-(2-hydroxyethoxy)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448273 CHEMBL570093 Bioactive (4S)-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)-4-[(2-phenyl-6-piperazin-1-ylpyrimidine-4-carbonyl)amino]pentanoic acid
CFAMM00448286 CHEMBL570242 Bioactive (4S)-4-[[6-[4-(2-methoxyethoxymethyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448260 CHEMBL570238 Bioactive (4S)-4-[[6-[4-[2-(diethylamino)-2-oxoethyl]piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448299 CHEMBL569915 Bioactive (4S)-4-[[6-[3-(dimethylamino)propylamino]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid
CFAMM00448312 CHEMBL571584 Bioactive (4S)-4-[[6-[4-(aminomethyl)piperidin-1-yl]-2-phenylpyrimidine-4-carbonyl]amino]-5-oxo-5-(4-pentoxycarbonylpiperazin-1-yl)pentanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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