CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18618
Family Name LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-[3-(2-hydroxyethylsulfamoyl)phenyl]-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00448331 Functional Category Bioactive
Superfamily RAC-alpha serine/threonine-protein kinase and Cyclin-A2 Binder Superfamily
Class Class 3138

Cousin Family NamesSeedsMembers
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine d... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00448329 CHEMBL566746 Bioactive (2S)-N-cyano-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-N'-[3-(propan-2-ylsulfamoyl)phenyl]piperazine-1-carboximidamide
CFAMM00448331 CHEMBL565453 Bioactive (2S)-N-cyano-N'-[3-(2-hydroxyethylsulfamoyl)phenyl]-2-methyl-4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboximidamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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