CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18619
Family Name Mitogen-activated protein kinase 1 and Aurora kinase A inhibitor pyrimidylpyrrole, 11a family
No. of Seeds 16 No. of Other Members 3
Family Centroid CFAMM00448334 Functional Category Bioactive
Superfamily Aurora kinase A and Adenosine deaminase Binder Superfamily
Class Class 3519

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Delavirdine Family 1 68
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Renin Inhibitor Remikiren Family 100 126
Prothrombin Inhibitor Dabigatran Family 7 182
Purine nucleoside phosphorylase Inhibitor BCX-34 Family 2 31
Reverse transcriptase Inhibitor IDX899 Family 2 118
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Growth hormone receptor Ligand EP-51216 Family 34 390
Adenosine receptor A1 Ligand SLV320 Family 6 79
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
NS5A protein Inhibitor Bms 790052 Family 5 9
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
JAK Inhibitor Momelotinib Family 33 83
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
PF-4136309 family 16 27
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M4U... 4 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Coagulation factor X inhibitor SureCN8289965 family 4 5
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Mitogen-activated protein kinase 1 inhibitor Pyrrole Carboxami... 3 12
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 8
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Tripeptidyl-peptidase 2 inhibitor (2S)-2-amino-1-[(2S)-5-chlor... 1 0
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 0
Egl nine homolog 1 inhibitor 2-[(1,6-diphenylimidazo[4,5-c]pyr... 1 5
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 3 1
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 1 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00448340 CHEMBL572162 Bioactive pyrimidylpyrrole, 9d
CFAMM00448346 CHEMBL576048 Bioactive pyrimidylpyrrole, 11f
CFAMM00448333 CHEMBL571038 Bioactive pyrimidylpyrrole, 9a
CFAMM00448339 CHEMBL583042 Bioactive VX-11e
CFAMM00448345 CHEMBL572157 Bioactive pyrimidylpyrrole, 11b
CFAMM00448338 CHEMBL571030 Bioactive pyrimidylpyrrole, 9e
CFAMM00448344 CHEMBL568483 Bioactive pyrimidylpyrrole, 11d
CFAMM00448343 CHEMBL568937 Bioactive pyrimidylpyrrole, 11h
CFAMM00448336 CHEMBL569869 Bioactive pyrimidylpyrrole, 10b
CFAMM00448335 CHEMBL571056 Bioactive pyrimidylpyrrole, 11g
CFAMM00448341 CHEMBL577193 Bioactive pyrimidylpyrrole, 10c
CFAMM00448334 CHEMBL571031 Bioactive pyrimidylpyrrole, 11a

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27396 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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