CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18643
Family Name Urotensin-2 receptor ligand 2-[(1R)-4-[(6-chloropyrazin-2-yl)amino]-1-(3,4-dimethoxyphenyl)butyl]-4-(4-ethylpiperazin-1-yl)-3H-isoindol-1-one family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00448489 Functional Category Bioactive
Superfamily Urotensin-2 receptor and 5-hydroxytryptamine receptor 6 Binder Superfamily
Class Class 2504

Cousin Family NamesSeedsMembers
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0


External ID

Functional Category

Molecule Name

CFAMM00448489 CHEMBL566056 Bioactive 2-[(1R)-4-[(6-chloropyrazin-2-yl)amino]-1-(3,4-dimethoxyphenyl)butyl]-4-(4-ethylpiperazin-1-yl)-3H-isoindol-1-one
CFAMM00448490 CHEMBL571625 Bioactive 2-[(1R)-1-(3,4-dimethoxyphenyl)-4-[(6-methoxypyrazin-2-yl)amino]butyl]-4-(4-ethylpiperazin-1-yl)-3H-isoindol-1-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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Computer-aided Drug Design
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