CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18686
Family Name Sodium-dependent noradrenaline transporter and Sodium-dependent serotonin transporter inhibitor SureCN4090002 family
No. of Seeds 5 No. of Other Members 7
Family Centroid CFAMM00235321 Functional Category Bioactive
Superfamily Prelamin-A/C and Nociceptin receptor Binder Superfamily
Class Class 3210

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Doxylamine Family 2 91
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Food vacuoles Inhibitor Mefloquine Family 2 25
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Grt 6005/06 family 4 22
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand (6-ben... 2 5
D(1B) dopamine receptor and D(2) dopamine receptor Ligand Flut... 1 6
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Progesterone receptor and Glucocorticoid receptor ligand SureC... 4 2
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 4 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 7 14
Glucocorticoid receptor ligand SureCN5650626 family 17 25
Glucocorticoid receptor ligand SureCN4198717 family 5 0
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Glucocorticoid receptor ligand AGN-PC-0A9RHA family 1 2
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Melanin-concentrating hormone receptor 2 ligand (2R)-1'-(9H-ca... 2 10
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Transporter and Sodium-dependent serotonin transporter inhibit... 2 1
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 5 8
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
Beta-3 adrenergic receptor ligand 3-[2-[[(2R)-2-(3-chloropheny... 1 1
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 3 9
Thromboxane-A synthase inhibitor AGN-PC-07BYVF family 1 0
Histamine H3 receptor ligand AGN-PC-09M6FC family 1 9
Rho-associated protein kinase 2 and Rho-associated protein kin... 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
Nociceptin receptor and Mu-type opioid receptor ligand SureCN1... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (2Z)-... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 4 2
Protein kinase C eta type and Protein kinase C epsilon type in... 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand [(7S)... 1 3
Nuclear receptor ROR-gamma and Prelamin-A/C ligand CHEMBL14461... 1 18
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00448774 CHEMBL609883 Bioactive indole, 14

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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