CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1869
Family Name Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(5-methylbenzimidazol-1-yl)ethylamino]-4-oxo-2-propan-2-ylbutanoyl]amino]-4-oxobutanoic acid family
No. of Seeds 5 No. of Other Members 27
Family Centroid CFAMM00328405 Functional Category Bioactive with Natural Product
Superfamily BIBT986 Superfamily
Class Class 716

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Translocator protein Inhibitor Emapunil Family 7 89
BIBT986 family 7 96
GDC-0349 family 44 77
JAK Inhibitor Momelotinib Family 33 83
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 6 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 1 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 1 0
Putative Bioactive N-[(2R)-2-[(2S)-2-(1H-benzimidazol-2-yl)pyr... 2 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
C-X-C chemokine receptor type 2 ligand (2S)-2-[[6-butyl-2-(4-m... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00328408 CHEMBL1221690 Bioactive (3S)-4-oxo-3-[[(2S)-4-oxo-2-propan-2-yl-4-[2-(2-pyridin-3-ylbenzimidazol-1-yl)ethylamino]butanoyl]amino]butanoic acid
CFAMM00328407 CHEMBL1221691 Bioactive (3S)-4-oxo-3-[[(2S)-4-oxo-2-propan-2-yl-4-[2-(2,5,6-trimethylbenzimidazol-1-yl)ethylamino]butanoyl]amino]butanoic acid
CFAMM00328392 CHEMBL1221689 Bioactive (3S)-3-[[(2S)-4-[2-(2-methylbenzimidazol-1-yl)ethylamino]-4-oxo-2-propan-2-ylbutanoyl]amino]-4-oxobutanoic acid
CFAMM00328391 CHEMBL1221688 Bioactive (3S)-3-[[(2S)-4-[2-(5,6-dimethylbenzimidazol-1-yl)ethylamino]-4-oxo-2-propan-2-ylbutanoyl]amino]-4-oxobutanoic acid
CFAMM00328405 CHEMBL1221647 Bioactive (3S)-3-[[(2S)-4-[2-(5-methylbenzimidazol-1-yl)ethylamino]-4-oxo-2-propan-2-ylbutanoyl]amino]-4-oxobutanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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