CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1872
Family Name Caspase-1 inhibitor (3S)-4-oxo-3-[[(2S)-4-oxo-2-propan-2-yl-4-(2-quinolin-4-ylethylamino)butanoyl]amino]butanoic acid family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00328413 Functional Category Bioactive
Superfamily Caspase-1 and Trypsin-1 Binder Superfamily
Class Class 1127

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
CBP-501 family 7 8
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Histone deacetylase Inhibitor ST-5732 Family 8 6
Cholecystokinin receptor type A ligand A-65186 family 2 6
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(1,2-dimethylindol-3-yl... 3 4
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Pancreatic alpha-amylase and Gastrin/cholecystokinin type B re... 7 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 4
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7013744... 2 3
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Protein kinase C delta type and Protein kinase C beta type inh... 4 4
Endothelin B receptor and Endothelin-1 receptor ligand 2-[[(2R... 17 10
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
Interstitial collagenase and Stromelysin-1 inhibitor CHEMBL887... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00328413 CHEMBL1221743 Bioactive (3S)-4-oxo-3-[[(2S)-4-oxo-2-propan-2-yl-4-(2-quinolin-4-ylethylamino)butanoyl]amino]butanoic acid
CFAMM00328412 CHEMBL1221811 Bioactive (3S)-3-[[(2S)-4-(2-isoquinolin-4-ylethylamino)-4-oxo-2-propan-2-ylbutanoyl]amino]-4-oxobutanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22932 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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