CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18765
Family Name Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymerase 2 inhibitor AGN-PC-077D4A family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00449054 Functional Category Bioactive
Superfamily Vascular endothelial growth factor receptor 2 Ligand XL999 Superfamily
Class Class 1053

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Delavirdine Family 1 68
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Tubulin beta chain Inhibitor Mebendazole Family 12 84
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Purine nucleoside phosphorylase Inhibitor BCX-34 Family 2 31
Transient receptor potential cation channel subfamily V member... 15 457
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Growth hormone receptor Ligand EP-51216 Family 34 390
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
NS5A protein Inhibitor Bms 790052 Family 5 9
BIBT986 family 7 96
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
IPI-145 family 2 4
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CC-486 family 7 103
JAK Inhibitor Momelotinib Family 33 83
Eluxadoline family 4 85
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Class II cytokine receptor Ligand IL-10 Family 7 45
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Serine/threonine-protein kinase Chk1 Inhibitor Granulatimide F... 1 1
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 2 3
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Telomerase reverse transcriptase Inhibitor NSC-745794 Family 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 16
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Prothrombin inhibitor SureCN5856722 family 3 16
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Insulin receptor and Tyrosine-protein kinase Lck ligand AGN-PC... 1 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Adenosine receptor A3 ligand AGN-PC-07N4XX family 6 10
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Platelet-activating factor receptor ligand 5-methyl-2-[4-(2-me... 1 2
Histamine H4 receptor ligand SureCN602132 family 1 8
Smoothened homolog inhibitor SureCN1091571 family 2 2
Transient receptor potential cation channel subfamily V member... 1 4
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 4 inhibitor Su... 5 13
Cannabinoid receptor 2 ligand AGN-PC-080WIY family 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Mitogen-activated protein kinase 14 inhibitor 3mvm family 6 1
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Tyrosine-protein kinase ABL1 inhibitor 5-[(5-{[4-{[4-(2-Hydrox... 4 1
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Adenosine receptor A2a ligand AGN-PC-01LVXW family 2 25
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M4U... 4 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Mitogen-activated protein kinase 14 inhibitor (E)-3-(2,6-dichl... 1 1
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Poly [ADP-ribose] polymerase 1 inhibitor ethyl 4-(4-carbamoyl-... 2 15
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Poly [ADP-ribose] polymerase 1 inhibitor SureCN6202744 family 4 2
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
Coagulation factor X and Trypsin-1 inhibitor 2-(5-carbamimidoy... 5 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 6 2
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 14
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Platelet-activating factor receptor ligand SureCN7491834 family 28 15
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Cannabinoid receptor 2 ligand AGN-PC-0A9SMV family 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 4
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 0
TGF-beta receptor type-1 ligand 3-[[3-(6-methylpyridin-2-yl)-4... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 11 0
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 2 1
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Transient receptor potential cation channel subfamily V member... 2 1
Heat shock protein HSP 90-beta inhibitor N-[(9R)-4-(3H-imidazo... 1 0
Serine/threonine-protein kinase Chk2 inhibitor SureCN3922132 f... 3 2
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Coagulation factor X inhibitor SureCN8289965 family 4 5
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 2
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Aurora kinase B and Cyclin-dependent kinase 1 inhibitor 7-cycl... 3 16
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Mitogen-activated protein kinase 14 inhibitor methyl 4-[5-(eth... 3 11
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Heat shock protein HSP 90-beta inhibitor 1-(2-amino-4-methylqu... 1 2
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 1 0
Aurora kinase B and Aurora kinase A inhibitor (2S)-1-[4-[[1-[(... 12 4
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 2 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Type-1 angiotensin II receptor ligand 7-methyl-N-(2-phenylethy... 2 10
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Cyclin-dependent kinase 2 and Serine/threonine-protein kinase ... 2 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 3 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Renin inhibitor AGN-PC-073MLF family 7 6
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 2
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 2 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
ALK tyrosine kinase receptor ligand N-[6-[[4-(2-hydroxypropan-... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Tyrosine-protein kinase SYK and Potassium voltage-gated channe... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(tria... 1 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
5-hydroxytryptamine receptor 2B ligand SureCN1299437 family 6 7
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Tyrosine-protein kinase SYK and Cytochrome P450 2D6 inhibitor ... 3 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-chloro... 2 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 12 3
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 3 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Prostaglandin E synthase inhibitor 2-(2-chloro-6-fluorophenyl)... 9 1
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 10 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 10 4
C-X-C chemokine receptor type 3 ligand AGN-PC-07CQOB family 17 10
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 3 0
Glycogen synthase kinase-3 beta inhibitor GSK-3beta Inhibitor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 3
Type-1 angiotensin II receptor ligand 2-[(2-ethyl-5,7-dimethyl... 5 3
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 13
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Glucocorticoid receptor ligand N-[2-[[[5-amino-1-(4-fluorophen... 1 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 0
Dipeptidyl peptidase 4 inhibitor SureCN5776796 family 1 0
Egl nine homolog 1 inhibitor 2-[(1,6-diphenylimidazo[4,5-c]pyr... 1 5
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Poly [ADP-ribose] polymerase 1 inhibitor 2-[4-(1,2-oxazol-5-yl... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor 2-[4-(5-sulfanylidene... 1 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-077DC5 family 2 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07B2Q... 6 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07RBL... 5 0
Type-1 angiotensin II receptor ligand 2-[[(5-ethylpyrazolo[1,5... 1 0
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Lyn in... 1 0
Cannabinoid receptor 2 ligand [(4S,4aR,8aS)-4-hydroxy-4-phenyl... 1 0
Mitogen-activated protein kinase kinase kinase 5 inhibitor 4-(... 2 0
Fatty acid synthase inhibitor 4-[1-[2,4-dimethyl-5-(6-methylsu... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0
Insulin-like growth factor 1 receptor and Cytochrome P450 3A4 ... 3 0
Reverse transcriptase/RNaseH inhibitor AC1LAPCJ family 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 2
Tyrosine-protein kinase JAK1 and Non-receptor tyrosine-protein... 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00449056 CHEMBL578804 Bioactive 2-[4-(1-methylpyrazol-3-yl)phenyl]-1H-benzimidazole-4-carboxamide
CFAMM00449055 CHEMBL576423 Bioactive AGN-PC-077DG9
CFAMM00449054 CHEMBL571285 Bioactive AGN-PC-077D4A
CFAMM00449057 CHEMBL577549 Bioactive AGN-PC-077D8A

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26821 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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