CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18772
Family Name Serine/threonine-protein kinase B-raf inhibitor (2R)-1-[3-[3-(1H-indazol-4-yl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-8-azabicyclo[3.2.1]octane-8-carbonyl]pyrrolidine-2-carboxylic acid family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00449073 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase B-raf and Phosphatidylinositol 3-kinase regulatory subunit alpha Binder Superfamily
Class Class 1024

Cousin Family NamesSeedsMembers
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Serine/threonine-protein kinase B-raf inhibitor SureCN1013857 ... 9 3
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Protein kinase C theta type and Protein kinase C delta type in... 9 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3496211 ... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00449073 CHEMBL571748 Bioactive (2R)-1-[3-[3-(1H-indazol-4-yl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]-8-azabicyclo[3.2.1]octane-8-carbonyl]pyrrolidine-2-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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