CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18776
Family Name Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-PC-00AVHB family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00449085 Functional Category Bioactive
Superfamily Coagulation factor X and Coagulation factor IX Binder Superfamily 3
Class Class 96

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Prothrombin Inhibitor Dabigatran Family 7 182
BIBT986 family 7 96
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Cannabinoid receptor 1 Ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 18 41
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 4
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Bile acid receptor and Potassium voltage-gated channel subfami... 2 1
Prothrombin inhibitor AGN-PC-09QLAK family 10 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 14
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 13
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Serine/threonine-protein kinase Chk2 inhibitor SureCN3922132 f... 3 2
Coagulation factor X inhibitor SureCN8289965 family 4 5
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 2
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Prostaglandin E synthase inhibitor 2-(2-chloro-6-fluorophenyl)... 9 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Substance-K receptor ligand SureCN9035669 family 10 5
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Coagulation factor X inhibitor SureCN1652469 family 2 1
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Lyn in... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00449085 CHEMBL572255 Bioactive AGN-PC-00AVHB

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27619 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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