CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18784
Family Name Serine/threonine-protein kinase pim-3 and Serine/threonine-protein kinase pim-1 inhibitor SureCN4199908 family
No. of Seeds 16 No. of Other Members 11
Family Centroid CFAMM00449139 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase pim-1 and Serine/threonine-protein kinase pim-3 Binder Superfamily 3
Class Class 3700

Cousin Family NamesSeedsMembers
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 2 5
Kinesin-like protein KIF11 inhibitor N-(3-aminopropyl)-N-[1-(3... 2 22
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 11
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 7
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 1 0


External ID

Functional Category

Molecule Name

CFAMM00449135 CHEMBL582844 Bioactive SureCN4210951
CFAMM00449148 CHEMBL576387 Bioactive 8-[(E)-2-cyclopropylethenyl]-2-[(dimethylamino)methyl]-1H-[1]benzothiolo[3,2-d]pyrimidin-4-one
CFAMM00449155 CHEMBL574169 Bioactive 8-(4-aminophenyl)-2-[(dimethylamino)methyl]-1H-[1]benzothiolo[3,2-d]pyrimidin-4-one
CFAMM00449140 CHEMBL576734 Bioactive SureCN2063072
CFAMM00449154 CHEMBL574168 Bioactive 2-[(dimethylamino)methyl]-8-ethynyl-1H-[1]benzothiolo[3,2-d]pyrimidin-4-one
CFAMM00449139 CHEMBL583273 Bioactive SureCN4199908
CFAMM00449153 CHEMBL583385 Bioactive 8-(3-chloro-5-fluorophenyl)-2-[(dimethylamino)methyl]-1H-[1]benzothiolo[3,2-d]pyrimidin-4-one
CFAMM00449138 CHEMBL575675 Bioactive 8-(4-chloro-3-fluorophenyl)-2-[(dimethylamino)methyl]-1H-[1]benzothiolo[3,2-d]pyrimidin-4-one
CFAMM00449144 CHEMBL575263 Bioactive SureCN4212107
CFAMM00449143 CHEMBL575471 Bioactive 8-(3,5-dichlorophenyl)-2-[(dimethylamino)methyl]-1H-[1]benzothiolo[3,2-d]pyrimidin-4-one
CFAMM00449136 CHEMBL584563 Bioactive 2-[(dimethylamino)methyl]-8-(4-methylthiophen-3-yl)-1H-[1]benzothiolo[3,2-d]pyrimidin-4-one
CFAMM00449142 CHEMBL573702 Bioactive SureCN4214613
CFAMM00449156 CHEMBL573470 Bioactive SureCN4212096

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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