CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1880
Family Name Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand SureCN9022846 family
No. of Seeds 8 No. of Other Members 21
Family Centroid CFAMM00328465 Functional Category Bioactive with Natural Product
Superfamily Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3-yl Acetate Superfamily
Class Class 2449

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Arachidonate 5-lipoxygenase Inhibitor MK-591 Family 9 161
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Apricoxib family 8 77
Indeglitazar family 3 39
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Integrin beta-3 Inhibitor L-756568 Family 8 59
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Renin Inhibitor CP-305202 Family 9 30
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 391
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Disintegrin and metalloproteinase domain-containing protein 17... 2 5
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
NS5B protein inhibitor AC1O5AET family 3 1
Glucagon receptor ligand 3-[[4-[(2S)-2-[5-(trifluoromethoxy)-1... 1 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 3 17
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 1
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
C-C chemokine receptor type 2 ligand (E)-1-[4-[2-hydroxy-1-[4-... 2 2
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 1 3
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 7 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 18 39
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 2 6
Serine/threonine-protein kinase Chk1 inhibitor 9-(1-methylpyrr... 1 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 1 4
Histamine H1 receptor and Histamine H2 receptor ligand SureCN6... 1 3
Histamine H1 receptor and Histamine H2 receptor ligand SureCN5... 3 6
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Phospholipase A2, membrane associated inhibitor 2-(1-benzyl-2-... 2 1
Caspase-3 and Caspase-7 inhibitor (2S)-N-[(3S)-2-hydroxy-5-oxo... 4 1
Histamine H1 receptor and Histamine H2 receptor ligand AGN-PC-... 1 1
Indoles Metabolite 4-[N-(p-Coumaroyl)serotonin-4''-yl]-N-ferul... 3 0
NP N-(1h-indol-6-yl)-3-(4-methoxy-1h-indol-1-yl)propanamide Fa... 2 0
Putative NP ZINC40309500 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00328471 CHEMBL125013 Bioactive SureCN6759616
CFAMM00328454 CHEMBL341116 Bioactive SureCN9023278
CFAMM00328482 CHEMBL122375 Bioactive (2E,4E)-5-[1-[2-[methyl(2-phenylethyl)amino]-2-oxoethyl]-5-phenylmethoxyindol-3-yl]penta-2,4-dienoic acid
CFAMM00328460 CHEMBL122217 Bioactive SureCN9022639
CFAMM00328474 CHEMBL127340 Bioactive SureCN9022946
CFAMM00328466 CHEMBL341360 Bioactive (2E,4E)-5-[1-[2-[methyl(2-phenylethyl)amino]-2-oxoethyl]-4-phenylmethoxyindol-3-yl]penta-2,4-dienoic acid
CFAMM00328465 CHEMBL127818 Bioactive SureCN9022846
CFAMM00328456 CHEMBL122852 Bioactive SureCN9023493

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27526 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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