CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM18920
Family Name Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethylbenzoyl)amino]-3-[4-[4-[(pyridin-2-ylamino)methyl]piperidin-1-yl]phenyl]propanoic acid family
No. of Seeds 9 No. of Other Members 1
Family Centroid CFAMM00172844 Functional Category Bioactive
Superfamily Integrin beta-1 and Integrin alpha-5 Binder Superfamily
Class Class 639

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Folate receptor gamma Ligand Folic Acid Family 4 100
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Prothrombin Inhibitor Dabigatran Family 7 182
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Thromboxane A2 receptor Ligand Bibv 308 Family 14 40
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Coagulation factor X Inhibitor Otamixaban Family 9 21
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
Class II cytokine receptor Ligand IL-10 Family 7 45
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Endothelin B receptor Ligand IRL-2500 Family 34 87
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(3,5... 28 18
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Cholecystokinin receptor type A ligand A-65186 family 2 6
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-3-quinolin... 6 8
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[[4-[2-(... 3 3
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
C-C chemokine receptor type 5 ligand AC1LA25C family 3 6
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6359092 f... 9 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 3 14
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 13 3
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-2-[[(1R,4S... 3 0
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
Pol polyprotein inhibitor Lysine Sulfonamide 6h family 1 1
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-2-(benzene... 3 2
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[5-methy... 4 5
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(4-fluo... 7 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(2,6-di... 6 5
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 3-methyl-4... 15 14
Poly [ADP-ribose] polymerase 1 inhibitor 8-[[4-fluoro-3-(4-pyr... 5 2
Lysine--tRNA ligase inhibitor 4-[[2-(2-piperazin-1-ylpyridin-4... 2 0
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
B1 bradykinin receptor ligand methyl 2-[4-[(1R)-1-[[3-[(2-cyan... 8 7
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
C-C chemokine receptor type 5 ligand AC1MHRXO family 5 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Aurora kinase A inhibitor Bisanilinopyrimidine, 6j family 2 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 7 6
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-00IW9E f... 3 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Integrin beta-1 and Integrin alpha-4 inhibitor (5R)-5-[[(2R)-2... 2 3
Coagulation factor VII inhibitor 2-[2-[(1-aminoisoquinolin-6-y... 1 14
Coagulation factor VII and Coagulation factor X inhibitor Ono ... 2 4
Integrin alpha-V and Integrin beta-6 inhibitor SureCN12259087 ... 3 4
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluor... 10 0
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5368289 f... 4 5
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methy... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Integrin beta-1 and Integrin alpha-5 inhibitor SureCN14453385 ... 5 0
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5370042 f... 8 0
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN5367895 f... 3 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Glutamate carboxypeptidase 2 inhibitor (2S)-2-[[(1S)-1-carboxy... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[4-(... 3 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-077MAQ fa... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[2-[(... 3 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-3-[4-[4-[[... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 1 1
Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1-(4-methylphenyl)sul... 1 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-3-[4-[5-[[... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00449751 CHEMBL590354 Bioactive SureCN4516020

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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